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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Heartworm prevention (6-/12-month injectable ProHeart; monthly topical Advantage Multi); extra-label generalized demodicosis (0.2–0.4 mg/kg PO q24h)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Heartworm prevention (6-/12-month injectable ProHeart; monthly topical Advantage Multi); extra-label generalized demodicosis (0.2–0.4 mg/kg PO q24h) — Authorized (label forms); demodex extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Heartworm prevention + fleas + parasites via topical combo
CatOn-label (ON_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Heartworm prevention + fleas + parasites via topical combo — Authorized (Advantage Multi/Advocate cat)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects203
Oral daily (demodex doses): vomiting, ataxia, lethargy, inappetence — Dose-limiting
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Neurotoxicity (tremors, coma) — MDR1-mutant dogs at high doses (ivermectin-rule applies); low-body-fat patients more prone
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Injection-site/procedure reactions (ProHeart) — Label-era safety history — why availability has fluctuated
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting14,339 reports
- Lack of efficacy (endoparasite) - heartworm10,751 reports
- Diarrhoea5,688 reports
- Lack of efficacy (endoparasite) - hookworm5,573 reports
- Lethargy (see also Central nervous system depression in 'Neurological')5,212 reports
- Anaphylaxis5,034 reports
- Facial swelling (see also 'Skin')3,718 reports
- INEFFECTIVE, HEARTWORM LARVAE3,186 reports
- Pruritus3,098 reports
- Anorexia2,783 reports
- Hives (see also 'Skin')2,704 reports
- Lack of efficacy (endoparasite) - roundworm NOS2,629 reports
Cat
- Lack of efficacy (ectoparasite) - flea1,643 reports
- Hypersalivation1,490 reports
- Lethargy (see also Central nervous system depression in 'Neurological')1,234 reports
- Application site alopecia1,181 reports
- Behavioural disorder NOS1,103 reports
- Pruritus839 reports
- Vomiting811 reports
- Application site hair loss791 reports
- Anorexia675 reports
- Ataxia622 reports
- Hyperactivity464 reports
- Application site pruritus417 reports
Monitoring1
Clinical: HW test annually + before restarts; demodex courses: neuro signs + skin scrapes q2–4 wk; weight for injectable dosing
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Hypersensitivity; HW-positive dogs (test before starting prevention — reactions to microfilariae + risk)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions9
>2-month dosing gap → retest before resuming; MDR1 status at demodicosis doses; cachectic/neonatal animals
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Prevention-safe vs treatment-risk split: the monthly microgram doses are MDR1-safe across genotypes (Mealey) — the DAILY demodicosis doses re-open the ivermectin-sensitivity question; know which regime you're dispensing.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
ProHeart's 6-month injection = the compliance solution for forgetful owners, with a regulatory-history asterisk (2004 recall, label changes).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Advantage Multi pairing: moxidectin (HW + parasites) + imidacloprid (fleas) in one spot-on — the combination-product era of parasiticide dispensing.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
ADVERSE REACTIONS Do not use on sick, debilitated, or underweight cats (See). Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight.
CatOn-label (ON_LABEL)United States1 source record · View provenance
- Cat · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Other avermectins — Don't stack macrocyclic lactones
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Imidacloprid (combo product) — Deliberate pairing
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Spinosad — High-dose-ivermectin-like interaction caution (class)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Avermectin: glutamate-gated chloride channels → parasite paralysis (class mechanism shared with ivermectin)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
MDR1 safety — HW-prevention doses (oral 3 µg/kg-class, topical 2.5 mg/kg) safe for ALL ABCB1 genotypes (Mealey) — but daily demodex doses carry ivermectin-like mutation risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Duration — Lipophilic depot (injectable = months)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Label statements per product; reproduction studies generally reassuring at preventive doses.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references6
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Evaluation of the speed-of-kill of Simparica Trio® against Ixodes ricinus in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy and safety of a sustained-release formulation of ivermectin (FILAPREV®) in preventing heartworm infection (Dirofilaria immitis) in dogs in two endemic areas of Italy.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of a formulation of the veterinary drug moxidectin on the performance of a plant-insect food chain.
Study summary not available in the imported record. Open the original citation to review the study.
- Pharmacokinetics of Moxidectin in Bare-Nosed Wombats (Vombatus ursinus) After Intravenous, Sub-Cutaneous and Transdermal Administration.
Study summary not available in the imported record. Open the original citation to review the study.
- Dung-applied anthelmintic drug moxidectin alters free-living soil nematode communities.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: DailyMed, U.S. National Library of Medicine; PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.