Regulatory product record
ADVANTAGE MULTI 18
Product identity, ingredients and source provenance from the regulatory catalogue. Linked clinical evidence has a separate review status.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Product identity
- Brand name
- ADVANTAGE MULTI 18
- DIN
- 02263513
- DPD drug code
- 74890
- Regulatory category
- APPROVED_VET_DRUG
- Market status
- MARKETED
- Route(s)
- TOPICAL
- Pharmaceutical form(s)
- SOLUTION
- Ingredients
- IMIDACLOPRID (80 MG), MOXIDECTIN (8 MG)
- Species (DPD record)
- CATS
- Company
- ELANCO CANADA LIMITED (DIN owner)
Source and provenance
- Source dataset
- health_canada_dpd_marketed
- Source snapshot date
- Not available in this source
- Source record key
- 74890
- Archive fingerprint (SHA-256)
- 85cc3ce208af3aa57018c3d14d83f90220c436baef7455384b6d48d9774e1c88
Linked clinical reference
Clinical entries are linked through the active molecule. Check their species, formulation, source and review status separately from this product record.
Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications9
Fleas — adult + larval (Advantage)
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Fleas — adult + larval (Advantage) — EPA-registered spot-on
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Fleas — adult + larval (Advantage) — EPA-registered spot-on
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
K9 Advantix: fleas + repel/kill ticks and mosquitoes (permethrin)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: K9 Advantix: fleas + repel/kill ticks and mosquitoes (permethrin) — Dog-only product
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Advantage Multi: HW prevention + fleas + hookworms/roundworms (+whipworms dog; ear mites cat) via moxidectin
DogCatOn-label (ON_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Advantage Multi: HW prevention + fleas + hookworms/roundworms (+whipworms dog; ear mites cat) via moxidectin — FDA-approved combo
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Advantage Multi: HW prevention + fleas + hookworms/roundworms (+whipworms dog; ear mites cat) via moxidectin — FDA-approved combo
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Sarcoptic mange, cheyletiellosis, mild demodicosis (combo products)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Sarcoptic mange, cheyletiellosis, mild demodicosis (combo products) — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Heartworm prevention (6-/12-month injectable ProHeart; monthly topical Advantage Multi); extra-label generalized demodicosis (0.2–0.4 mg/kg PO q24h)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Heartworm prevention (6-/12-month injectable ProHeart; monthly topical Advantage Multi); extra-label generalized demodicosis (0.2–0.4 mg/kg PO q24h) — Authorized (label forms); demodex extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens13
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Select a species above to calculate a dose.
Adverse effects406
Application-site irritation, temporary wet/oily hair — Minor
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Permethrin toxicity in cats: tremors, seizures, hyperthermia (from DOG product applied to cat or close contact) — The classic toxicology call
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Moxidectin-component cautions (HW-positive dogs) — Per combo label
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Oral daily (demodex doses): vomiting, ataxia, lethargy, inappetence — Dose-limiting
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Neurotoxicity (tremors, coma) — MDR1-mutant dogs at high doses (ivermectin-rule applies); low-body-fat patients more prone
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting14,339 reports
- Lack of efficacy (endoparasite) - heartworm10,751 reports
- Diarrhoea5,688 reports
- Lack of efficacy (endoparasite) - hookworm5,573 reports
- Lethargy (see also Central nervous system depression in 'Neurological')5,212 reports
- Anaphylaxis5,034 reports
- Facial swelling (see also 'Skin')3,718 reports
- Lack of efficacy (ectoparasite) - flea3,277 reports
- INEFFECTIVE, HEARTWORM LARVAE3,186 reports
- Pruritus3,098 reports
- Anorexia2,783 reports
- Hives (see also 'Skin')2,704 reports
Cat
- Lack of efficacy (ectoparasite) - flea1,643 reports
- Hypersalivation1,490 reports
- Lack of efficacy (ectoparasite) - flea1,412 reports
- Hypersalivation1,402 reports
- Lethargy (see also Central nervous system depression in 'Neurological')1,234 reports
- Application site alopecia1,181 reports
- Application site alopecia1,124 reports
- Behavioural disorder NOS1,103 reports
- Lethargy (see also Central nervous system depression in 'Neurological')1,102 reports
- Behavioural disorder NOS1,049 reports
- Pruritus935 reports
- Pruritus839 reports
Monitoring2
Parasite control; cat-dog households (permethrin exposure); HW testing for combos
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Clinical: HW test annually + before restarts; demodex courses: neuro signs + skin scrapes q2–4 wk; weight for injectable dosing
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications6
K9 Advantix (permethrin) in/on cats — dog households with cats need separated application + drying
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hypersensitivity; HW-positive dogs (test before starting prevention — reactions to microfilariae + risk)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
DO NOT ADMINISTER THIS PRODUCT ORALLY For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with application sites for two (2) hours after application. Contraindications Warnings Human Warnings Adverse Reactions (See,,, and, for more information)
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34066-1 (BOXED WARNING SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
WARNINGS Do not administer this product orally. (See.) Do not use this product (containing 2.5 % moxidectin) on cats.
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
DO NOT ADMINISTER THIS PRODUCT ORALLY For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with application sites for two (2) hours after application. Contraindications Warnings Human Warnings, Adverse Reactions (See,,and, for more information)
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34066-1 (BOXED WARNING SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Precautions30
HW test before moxidectin combos
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The cat-permethrin disaster is the #1 client-education point in topical parasiticides: Advantix on the dog, cat grooming against it → tremoring cat at 2 AM.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
One base molecule, three product personalities: flea-only (Advantage), flea-tick-mosquito-dog (Advantix), flea-HW-parasite (Multi) — read the suffix, not just the brand.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
>2-month dosing gap → retest before resuming; MDR1 status at demodicosis doses; cachectic/neonatal animals
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Prevention-safe vs treatment-risk split: the monthly microgram doses are MDR1-safe across genotypes (Mealey) — the DAILY demodicosis doses re-open the ivermectin-sensitivity question; know which regime you're dispensing.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions4
Other spot-ons — Space sites/dates
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Other avermectins — Don't stack macrocyclic lactones
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Imidacloprid (combo product) — Deliberate pairing
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Spinosad — High-dose-ivermectin-like interaction caution (class)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics7
Mechanism — Nicotinic ACh receptor (post-synaptic, insect) agonist-blocker → CNS impairment/death — different site from OPs/pyrethrins/IGRs
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Permethrin (combo) — Pyrethroid sodium-channel neurotoxin — repels + kills ticks/mosquitoes; cat metabolism (glucuronidation-deficient) cannot clear it → toxicity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Moxidectin (combo) — Macrocyclic lactone — HW/intestinal parasites (see moxidectin.md)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Absorption — Manufacturer: topical imidacloprid not absorbed into bloodstream/organs
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Mechanism — Avermectin: glutamate-gated chloride channels → parasite paralysis (class mechanism shared with ivermectin)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations2
Manufacturer non-teratogenic/mutagenic/carcinogenic claims; label use generally permitted.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Label statements per product; reproduction studies generally reassuring at preventive doses.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references24
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Behavioral Effects and Potential Mechanisms of Imidacloprid- and Flupyradifurone-Induced Neurotoxicity in Caenorhabditis elegans.
Study summary not available in the imported record. Open the original citation to review the study.
- Combined toxic impacts of imidacloprid and epoxiconazole on Apis mellifera L. and the underlying mechanism.
Study summary not available in the imported record. Open the original citation to review the study.
- A human biomonitoring study evaluating exposure to imidacloprid among pet owners following the use of ectoparasite treatments.
Study summary not available in the imported record. Open the original citation to review the study.
- Integrative network toxicology and multi-omics analysis reveals potential mechanisms of imidacloprid-induced neurotoxicity in SH-SY5Y cells and Caenorhabditis elegans.
Study summary not available in the imported record. Open the original citation to review the study.
- Field evaluation of a topical combination of ivermectin, imidacloprid, and praziquantel for flea control in cats under routine clinical.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: DailyMed, U.S. National Library of Medicine; PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.