Regulatory product record
CREDELIO QUATTRO
Product identity, ingredients and source provenance from the regulatory catalogue. Linked clinical evidence has a separate review status.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Product identity
- Brand name
- CREDELIO QUATTRO
- DIN
- 02567539
- DPD drug code
- 106994
- Regulatory category
- APPROVED_VET_DRUG
- Market status
- MARKETED
- Route(s)
- ORAL
- Pharmaceutical form(s)
- TABLET
- Ingredients
- LOTILANER (900 MG), MOXIDECTIN (0.9 MG), PYRANTEL (PYRANTEL PAMOATE) (657.12 MG), PRAZIQUANTEL (228 MG)
- Species (DPD record)
- DOGS
- Company
- ELANCO CANADA LIMITED (DIN owner)
Source and provenance
- Source dataset
- health_canada_dpd_marketed
- Source snapshot date
- Not available in this source
- Source record key
- 106994
- Archive fingerprint (SHA-256)
- 85cc3ce208af3aa57018c3d14d83f90220c436baef7455384b6d48d9774e1c88
Linked clinical reference
Clinical entries are linked through the active molecule. Check their species, formulation, source and review status separately from this product record.
Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications4
Heartworm prevention (6-/12-month injectable ProHeart; monthly topical Advantage Multi); extra-label generalized demodicosis (0.2–0.4 mg/kg PO q24h)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Heartworm prevention (6-/12-month injectable ProHeart; monthly topical Advantage Multi); extra-label generalized demodicosis (0.2–0.4 mg/kg PO q24h) — Authorized (label forms); demodex extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Heartworm prevention + fleas + parasites via topical combo
CatOn-label (ON_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Heartworm prevention + fleas + parasites via topical combo — Authorized (Advantage Multi/Advocate cat)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus (and E. multilocularis)
DogOn-label (ON_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus (and E. multilocularis) — FDA-approved (labeled)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dipylidium caninum, Taenia taeniaeformis
CatOn-label (ON_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Dipylidium caninum, Taenia taeniaeformis — FDA-approved (labeled)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens11
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Select a species above to calculate a dose.
Adverse effects808
Oral daily (demodex doses): vomiting, ataxia, lethargy, inappetence — Dose-limiting
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Neurotoxicity (tremors, coma) — MDR1-mutant dogs at high doses (ivermectin-rule applies); low-body-fat patients more prone
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Injection-site/procedure reactions (ProHeart) — Label-era safety history — why availability has fluctuated
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Uncommon overall (oral use) — <5% (dog), <2% (cat)
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Anorexia, vomiting, lethargy, diarrhea (oral) — Uncommon
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting37,307 reports
- INEFFECTIVE, HEARTWORM LARVAE35,850 reports
- Lack of efficacy (endoparasite) - hookworm31,823 reports
- Lack of efficacy (endoparasite) - heartworm28,953 reports
- Digestive tract disorder NOS16,793 reports
- Diarrhoea15,908 reports
- Vomiting15,638 reports
- Vomiting14,339 reports
- INEFFECTIVE, ASCARIDS NOS11,932 reports
- Lack of efficacy (endoparasite) - heartworm10,751 reports
- Cardiac disorder NOS10,065 reports
- Lethargy (see also Central nervous system depression in 'Neurological')9,427 reports
Cat
- Lack of efficacy (ectoparasite) - flea1,643 reports
- Hypersalivation1,636 reports
- Vomiting1,595 reports
- Application site alopecia1,497 reports
- Hypersalivation1,490 reports
- Lethargy (see also Central nervous system depression in 'Neurological')1,234 reports
- Ataxia1,224 reports
- Application site alopecia1,181 reports
- Behavioural disorder NOS1,103 reports
- Lethargy (see also Central nervous system depression in 'Neurological')1,052 reports
- Lack of efficacy (endoparasite) - tapeworm906 reports
- Pruritus839 reports
Monitoring2
Clinical: HW test annually + before restarts; demodex courses: neuro signs + skin scrapes q2–4 wk; weight for injectable dosing
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Fecal exam to confirm efficacy; reinfection is common with D. caninum given ongoing flea exposure — counsel concurrent flea control
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications2
Hypersensitivity; HW-positive dogs (test before starting prevention — reactions to microfilariae + risk)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Manufacturer: avoid in puppies <4 weeks or kittens <6 weeks (though praziquantel/febantel combo is approved for all ages); hypersensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions13
>2-month dosing gap → retest before resuming; MDR1 status at demodicosis doses; cachectic/neonatal animals
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Prevention-safe vs treatment-risk split: the monthly microgram doses are MDR1-safe across genotypes (Mealey) — the DAILY demodicosis doses re-open the ivermectin-sensitivity question; know which regime you're dispensing.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
ProHeart's 6-month injection = the compliance solution for forgetful owners, with a regulatory-history asterisk (2004 recall, label changes).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Advantage Multi pairing: moxidectin (HW + parasites) + imidacloprid (fleas) in one spot-on — the combination-product era of parasiticide dispensing.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
None major beyond age restriction on monotherapy product
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions4
Other avermectins — Don't stack macrocyclic lactones
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Imidacloprid (combo product) — Deliberate pairing
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Spinosad — High-dose-ivermectin-like interaction caution (class)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Grapefruit juice — ↑ praziquantel AUC 150–200% in dogs (avoid coadministration if practical)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics6
Mechanism — Avermectin: glutamate-gated chloride channels → parasite paralysis (class mechanism shared with ivermectin)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
MDR1 safety — HW-prevention doses (oral 3 µg/kg-class, topical 2.5 mg/kg) safe for ALL ABCB1 genotypes (Mealey) — but daily demodex doses carry ivermectin-like mutation risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Duration — Lipophilic depot (injectable = months)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Bioavailability — Rapid, near-complete oral absorption but significant first-pass effect
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Hepatic, CYP3A
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations2
Label statements per product; reproduction studies generally reassuring at preventive doses.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Considered safe in pregnant dogs/cats and during lactation. Human FDA category B. Papich class A. Excreted in milk (~25% of maternal serum concentration) — unlikely to harm nursing offspring.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references36
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Oral lotilaner in 21 cats with naturally acquired harvest mite infestation.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy of Credelio Quattro™ chewable tablets containing lotilaner, moxidectin, pyrantel, and praziquantel against Ctenocephalides felis and Rhipicephalus sanguineus infestations on dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy of a novel chewable tablet (Credelio Quattro™) containing lotilaner, moxidectin, praziquantel, and pyrantel for the prevention of heartworm disease (Dirofilaria immitis) in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Long-term safety of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets), a novel orally administered combination endectocide for dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) and Credelio™ (lotilaner) chewable tablets in the prevention of Borrelia burgdorferi transmission from infected Ixodes scapularis in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: DailyMed, U.S. National Library of Medicine; PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.