Regulatory product record
SIMPARICA TRIO
Product identity, ingredients and source provenance from the regulatory catalogue. Linked clinical evidence has a separate review status.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Product identity
- Brand name
- SIMPARICA TRIO
- DIN
- 02492652
- DPD drug code
- 98263
- Regulatory category
- APPROVED_VET_DRUG
- Market status
- MARKETED
- Route(s)
- ORAL
- Pharmaceutical form(s)
- TABLET (CHEWABLE)
- Ingredients
- PYRANTEL (PYRANTEL PAMOATE) (12.5 MG), MOXIDECTIN (0.06 MG), SAROLANER (3 MG)
- Species (DPD record)
- DOGS
- Company
- ZOETIS CANADA INC (DIN owner)
Source and provenance
- Source dataset
- health_canada_dpd_marketed
- Source snapshot date
- Not available in this source
- Source record key
- 98263
- Archive fingerprint (SHA-256)
- 85cc3ce208af3aa57018c3d14d83f90220c436baef7455384b6d48d9774e1c88
Linked clinical reference
Clinical entries are linked through the active molecule. Check their species, formulation, source and review status separately from this product record.
Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Heartworm prevention (6-/12-month injectable ProHeart; monthly topical Advantage Multi); extra-label generalized demodicosis (0.2–0.4 mg/kg PO q24h)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Heartworm prevention (6-/12-month injectable ProHeart; monthly topical Advantage Multi); extra-label generalized demodicosis (0.2–0.4 mg/kg PO q24h) — Authorized (label forms); demodex extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Heartworm prevention + fleas + parasites via topical combo
CatOn-label (ON_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Heartworm prevention + fleas + parasites via topical combo — Authorized (Advantage Multi/Advocate cat)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Select a species above to calculate a dose.
Adverse effects603
Oral daily (demodex doses): vomiting, ataxia, lethargy, inappetence — Dose-limiting
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Neurotoxicity (tremors, coma) — MDR1-mutant dogs at high doses (ivermectin-rule applies); low-body-fat patients more prone
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Injection-site/procedure reactions (ProHeart) — Label-era safety history — why availability has fluctuated
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting37,307 reports
- INEFFECTIVE, HEARTWORM LARVAE35,850 reports
- Lack of efficacy (endoparasite) - hookworm31,823 reports
- Lack of efficacy (endoparasite) - heartworm28,953 reports
- Digestive tract disorder NOS16,793 reports
- Diarrhoea15,908 reports
- Vomiting14,339 reports
- Vomiting12,831 reports
- INEFFECTIVE, ASCARIDS NOS11,932 reports
- Lack of efficacy (endoparasite) - heartworm10,751 reports
- Cardiac disorder NOS10,065 reports
- Lethargy (see also Central nervous system depression in 'Neurological')9,427 reports
Cat
- Application site hair loss2,294 reports
- Lack of efficacy (ectoparasite) - flea1,643 reports
- Hypersalivation1,490 reports
- Lethargy (see also Central nervous system depression in 'Neurological')1,234 reports
- Application site alopecia1,181 reports
- Behavioural disorder NOS1,103 reports
- Pruritus839 reports
- Vomiting811 reports
- Application site hair loss791 reports
- Application site alopecia707 reports
- Application site scab686 reports
- Lack of efficacy (ectoparasite) - flea685 reports
Monitoring1
Clinical: HW test annually + before restarts; demodex courses: neuro signs + skin scrapes q2–4 wk; weight for injectable dosing
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Hypersensitivity; HW-positive dogs (test before starting prevention — reactions to microfilariae + risk)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions9
>2-month dosing gap → retest before resuming; MDR1 status at demodicosis doses; cachectic/neonatal animals
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Prevention-safe vs treatment-risk split: the monthly microgram doses are MDR1-safe across genotypes (Mealey) — the DAILY demodicosis doses re-open the ivermectin-sensitivity question; know which regime you're dispensing.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
ProHeart's 6-month injection = the compliance solution for forgetful owners, with a regulatory-history asterisk (2004 recall, label changes).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Advantage Multi pairing: moxidectin (HW + parasites) + imidacloprid (fleas) in one spot-on — the combination-product era of parasiticide dispensing.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
ADVERSE REACTIONS Do not use on sick, debilitated, or underweight cats (See). Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight.
CatOn-label (ON_LABEL)United States1 source record · View provenance
- Cat · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Other avermectins — Don't stack macrocyclic lactones
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Imidacloprid (combo product) — Deliberate pairing
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Spinosad — High-dose-ivermectin-like interaction caution (class)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Avermectin: glutamate-gated chloride channels → parasite paralysis (class mechanism shared with ivermectin)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
MDR1 safety — HW-prevention doses (oral 3 µg/kg-class, topical 2.5 mg/kg) safe for ALL ABCB1 genotypes (Mealey) — but daily demodex doses carry ivermectin-like mutation risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Duration — Lipophilic depot (injectable = months)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Label statements per product; reproduction studies generally reassuring at preventive doses.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 864–866 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references15
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Evaluation of the speed-of-kill of Simparica Trio® against Ixodes ricinus in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy and safety of a sustained-release formulation of ivermectin (FILAPREV®) in preventing heartworm infection (Dirofilaria immitis) in dogs in two endemic areas of Italy.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of a formulation of the veterinary drug moxidectin on the performance of a plant-insect food chain.
Study summary not available in the imported record. Open the original citation to review the study.
- Pharmacokinetics of Moxidectin in Bare-Nosed Wombats (Vombatus ursinus) After Intravenous, Sub-Cutaneous and Transdermal Administration.
Study summary not available in the imported record. Open the original citation to review the study.
- Dung-applied anthelmintic drug moxidectin alters free-living soil nematode communities.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: DailyMed, U.S. National Library of Medicine; PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.