Favorites and recent references stay on this device. No patient data is stored.
Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications7
Fleas — adult + larval (Advantage)
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Fleas — adult + larval (Advantage) — EPA-registered spot-on
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Fleas — adult + larval (Advantage) — EPA-registered spot-on
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
K9 Advantix: fleas + repel/kill ticks and mosquitoes (permethrin)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: K9 Advantix: fleas + repel/kill ticks and mosquitoes (permethrin) — Dog-only product
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Advantage Multi: HW prevention + fleas + hookworms/roundworms (+whipworms dog; ear mites cat) via moxidectin
DogCatOn-label (ON_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Advantage Multi: HW prevention + fleas + hookworms/roundworms (+whipworms dog; ear mites cat) via moxidectin — FDA-approved combo
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Advantage Multi: HW prevention + fleas + hookworms/roundworms (+whipworms dog; ear mites cat) via moxidectin — FDA-approved combo
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Sarcoptic mange, cheyletiellosis, mild demodicosis (combo products)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Sarcoptic mange, cheyletiellosis, mild demodicosis (combo products) — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Midamox for Dogs Dirofilaria immitis Dirofilaria immitis Midamox for Dogs Ctenocephalides felis Midamox for Dogs Sarcoptes scabiei canis. Midamox for Dogs is indicated for the prevention of heartworm disease caused byand the treatment ofcirculating microfilariae in heartworm-positive dogs.kills adult fleas and is indicated for the treatment of flea infestations ().is indicated for the treatment and control of sarcoptic mange caused byvar.is also indicated for the treatment and control of the following intestinal parasites: Intestinal Parasite Intestinal Stage Adult Immature Adult Fourth Stage Larvae Hookworm Species Ancylostoma caninum X X X Uncinaria stenocephala X X X Roundworm Species Toxocara canis X X Toxascaris leonina X Whipworm Trichuris vulpis X
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens8
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects203
Application-site irritation, temporary wet/oily hair — Minor
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Permethrin toxicity in cats: tremors, seizures, hyperthermia (from DOG product applied to cat or close contact) — The classic toxicology call
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Moxidectin-component cautions (HW-positive dogs) — Per combo label
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Lack of efficacy (ectoparasite) - flea3,277 reports
- Pruritus2,083 reports
- Vomiting1,937 reports
- Lethargy (see also Central nervous system depression in 'Neurological')1,855 reports
- Behavioural disorder NOS1,372 reports
- Diarrhoea1,285 reports
- Other abnormal test result NOS1,045 reports
- Lack of efficacy (endoparasite) - heartworm941 reports
- Anorexia898 reports
- INEFFECTIVE, HEARTWORM LARVAE777 reports
- Ataxia727 reports
- Seizure NOS608 reports
Cat
- Lack of efficacy (ectoparasite) - flea1,412 reports
- Hypersalivation1,402 reports
- Application site alopecia1,124 reports
- Lethargy (see also Central nervous system depression in 'Neurological')1,102 reports
- Behavioural disorder NOS1,049 reports
- Pruritus935 reports
- Vomiting754 reports
- Anorexia679 reports
- Ataxia529 reports
- Application site pruritus437 reports
- Hyperactivity436 reports
- Application site erythema395 reports
Monitoring1
Parasite control; cat-dog households (permethrin exposure); HW testing for combos
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications5
K9 Advantix (permethrin) in/on cats — dog households with cats need separated application + drying
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
DO NOT ADMINISTER THIS PRODUCT ORALLY For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with application sites for two (2) hours after application. Contraindications Warnings Human Warnings Adverse Reactions (See,,, and, for more information)
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34066-1 (BOXED WARNING SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
WARNINGS Do not administer this product orally. (See.) Do not use this product (containing 2.5 % moxidectin) on cats.
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
DO NOT ADMINISTER THIS PRODUCT ORALLY For the first 30 minutes after application ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with application sites for two (2) hours after application. Contraindications Warnings Human Warnings, Adverse Reactions (See,,and, for more information)
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34066-1 (BOXED WARNING SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
WARNINGS. Do not administer this product orally. (See) Do not use this product (containing 2.5% moxidectin) on cats.
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Precautions21
HW test before moxidectin combos
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The cat-permethrin disaster is the #1 client-education point in topical parasiticides: Advantix on the dog, cat grooming against it → tremoring cat at 2 AM.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
One base molecule, three product personalities: flea-only (Advantage), flea-tick-mosquito-dog (Advantix), flea-HW-parasite (Multi) — read the suffix, not just the brand.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
For the first 30 minutes after application: Ensure that dogs cannot lick the product from application sites on themselves or other treated dogs, and Separate treated dogs from one another and from other pets to reduce the risk of accidental ingestion. Ingestion of this product by dogs may cause serious adverse reactions including depression, salivation, dilated pupils, incoordination, panting, and generalized muscle tremors. In avermectin sensitive dogs, a the signs may be more severe and may include coma and death. b a Some dogs are more sensitive to avermectins due to a mutation in the MDR1 gene. Dogs with this mutation may develop signs of severe avermectin toxicity if they ingest this product. The most common breeds associated with this mutation include Collies and Collie crosses. b Although there is no specific antagonist for avermectin toxicity, even severely affected dogs have completely recovered from avermectin toxicity with intensive veterinary supportive care.
DogOn-label (ON_LABEL)United States2 source records · View provenance
- Dog · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Dog · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Do not dispense dose applicators without complete safety and administration information. Midamox for Cats Avoid oral ingestion. Cats may experience hypersalivation, tremors, vomiting and decreased appetite ifis inadvertently administered orally or through grooming/licking of the application site. Midamox for Cats The safety ofhas not been established in breeding, pregnant, or lactating cats. Midamox for Cats D. immitis The effectiveness ofagainst heartworm infections () after bathing has not been evaluated in cats. ADVERSE REACTIONS. (See) Use of this product in geriatric patients with subclinical conditions has not been adequately studied. Several otherwise healthy, thin geriatric cats experienced prolonged lethargy and sleepiness after using this drug.
CatOn-label (ON_LABEL)United States2 source records · View provenance
- Cat · SPL section 42232-9 (PRECAUTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Cat · SPL section 42232-9 (PRECAUTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Interactions1
Other spot-ons — Space sites/dates
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics4
Mechanism — Nicotinic ACh receptor (post-synaptic, insect) agonist-blocker → CNS impairment/death — different site from OPs/pyrethrins/IGRs
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Permethrin (combo) — Pyrethroid sodium-channel neurotoxin — repels + kills ticks/mosquitoes; cat metabolism (glucuronidation-deficient) cannot clear it → toxicity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Moxidectin (combo) — Macrocyclic lactone — HW/intestinal parasites (see moxidectin.md)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Absorption — Manufacturer: topical imidacloprid not absorbed into bloodstream/organs
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Manufacturer non-teratogenic/mutagenic/carcinogenic claims; label use generally permitted.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1244–1245 (topical appendix) — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references18
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Behavioral Effects and Potential Mechanisms of Imidacloprid- and Flupyradifurone-Induced Neurotoxicity in Caenorhabditis elegans.
Study summary not available in the imported record. Open the original citation to review the study.
- Combined toxic impacts of imidacloprid and epoxiconazole on Apis mellifera L. and the underlying mechanism.
Study summary not available in the imported record. Open the original citation to review the study.
- A human biomonitoring study evaluating exposure to imidacloprid among pet owners following the use of ectoparasite treatments.
Study summary not available in the imported record. Open the original citation to review the study.
- Integrative network toxicology and multi-omics analysis reveals potential mechanisms of imidacloprid-induced neurotoxicity in SH-SY5Y cells and Caenorhabditis elegans.
Study summary not available in the imported record. Open the original citation to review the study.
- Field evaluation of a topical combination of ivermectin, imidacloprid, and praziquantel for flea control in cats under routine clinical.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: DailyMed, U.S. National Library of Medicine; PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.