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Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
No clinical assertions recorded for an overview.
View full clinical evidence and sources ↓Clinical evidence
Dose regimens0
No dose regimens recorded for this species selection.
Adverse effects200
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting37,307 reports
- INEFFECTIVE, HEARTWORM LARVAE35,850 reports
- Lack of efficacy (endoparasite) - hookworm31,823 reports
- Lack of efficacy (endoparasite) - heartworm28,953 reports
- Digestive tract disorder NOS16,793 reports
- Diarrhoea15,908 reports
- INEFFECTIVE, ASCARIDS NOS11,932 reports
- Cardiac disorder NOS10,065 reports
- Lethargy (see also Central nervous system depression in 'Neurological')9,427 reports
- Lack of efficacy (endoparasite) - roundworm NOS9,179 reports
- Lack of efficacy - NOS8,770 reports
- Seizure NOS7,555 reports
Cat
- Ataxia510 reports
- Vomiting467 reports
- Lethargy (see also Central nervous system depression in 'Neurological')216 reports
- Anorexia181 reports
- Diarrhoea158 reports
- Death135 reports
- Depression131 reports
- Behavioural disorder NOS108 reports
- Accidental exposure102 reports
- Hypersalivation98 reports
- Fever87 reports
- Emesis86 reports
Literature references4
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Efficacy of Simparica and Simparica TRIO for the prevention of Borrelia burgdorferi by Ixodes scapularis.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy of sarolaner in Simparica(®) (sarolaner) chewables and Simparica Trio(®) (sarolaner, moxidectin, and pyrantel chewable tablets) against two US strains of Haemaphysalis longicornis.
Study summary not available in the imported record. Open the original citation to review the study.
- Simparica Trio(®) kills Ctenocephalides felis on dogs and provides month-long protection against the transmission of Dipylidium caninum.
Study summary not available in the imported record. Open the original citation to review the study.
- Treatment efficacy of pyrantel, fenbendazole and macrocyclic lactones in equine strongyles in Germany using FECRT and the model eggCounts.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.