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Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Skin/soft tissue, bone, UTI, pneumonia, intracellular organisms (Mycoplasma haemofelis)
DogCatOn-label (ON_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Skin/soft tissue, bone, UTI, pneumonia, intracellular organisms (Mycoplasma haemofelis) — Authorized (FDA)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Skin/soft tissue, bone, UTI, pneumonia, intracellular organisms (Mycoplasma haemofelis) — Authorized (FDA)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects204
GI (nausea, vomiting, diarrhea), decreased activity — Occasional
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cartilage/articular injury — Young dogs (4–28 wk) and cats (8 mo, high doses 17–28 mg/kg x 42 days)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Ocular toxicity — No confirmed clinical cases in cats at labeled doses (unlike enrofloxacin); manufacturer studies at 3–5x dose showed no ocular lesions
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting208 reports
- Anorexia166 reports
- Lack of efficacy (bacteria) - NOS140 reports
- Lethargy (see also Central nervous system depression in 'Neurological')101 reports
- Depression99 reports
- Death by euthanasia89 reports
- Ataxia77 reports
- Death74 reports
- Other abnormal test result NOS74 reports
- Diarrhoea73 reports
- Elevated serum alkaline phosphatase (SAP)65 reports
- Elevated alanine aminotransferase (ALT)64 reports
Cat
- Anorexia84 reports
- Vomiting82 reports
- Lack of efficacy (bacteria) - NOS68 reports
- Death by euthanasia56 reports
- Weight loss51 reports
- Blindness44 reports
- Depression44 reports
- Death43 reports
- Ataxia41 reports
- Anaemia NOS37 reports
- Elevated blood urea nitrogen (BUN)37 reports
- Behavioural disorder NOS35 reports
Monitoring1
Clinical efficacy, adverse effect signs
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Fluoroquinolone hypersensitivity; food-producing animals (US)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions3
Young/growing animals (cartilage injury risk); seizure-prone patients
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Appears to carry a lower reported risk of feline retinal toxicity than enrofloxacin at labeled doses, though data is still limited — do not assume it is risk-free in young/growing animals regarding cartilage injury.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
European dosing (2 mg/kg) has shown efficacy for pyoderma even though US label minimum is 2.75 mg/kg — flexibility exists within the approved range.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions2
Antacids/cations (aluminum, iron, calcium — e.g., sucralfate) — ↓ absorption
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Theophylline — ↑ levels (less pronounced than with enrofloxacin)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Bioavailability — ~94% (dog); near-complete (cat)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — Low
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — 7–12h (dog); ~13h (cat)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — ~15% hepatic
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — ~40% renal unchanged + bile/feces
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Safety not established.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references15
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Fungal dysbiosis following antibacterial monotherapy in canine otitis externa.
Study summary not available in the imported record. Open the original citation to review the study.
- Diet-Induced Bloat in Confiscated Capped Langurs (Trachypithecus pileatus): Clinical Management and Conservation Implications.
Study summary not available in the imported record. Open the original citation to review the study.
- The Impact of Ketoprofen on the Pharmacokinetics of Marbofloxacin at Variable Intravenous Doses in Sheep.
Study summary not available in the imported record. Open the original citation to review the study.
- Effect of marbofloxacin and cefazolin concentrations and bacterial count on lipopolysaccharide (LPS) release by Escherichia coli and Klebsiella pneumoniae isolated from bovine clinical mastitis.
Study summary not available in the imported record. Open the original citation to review the study.
- In vitro efficacy of antibiotics and bacteriophages against Pseudomonas aeruginosa isolates from clinically affected captive falcons in Dubai, United Arab Emirates.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.