Regulatory product record
AURIZON
Product identity, ingredients and source provenance from the regulatory catalogue. Linked clinical evidence has a separate review status.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Product identity
- Brand name
- AURIZON
- DIN
- 02353970
- DPD drug code
- 83919
- Regulatory category
- APPROVED_VET_DRUG
- Market status
- MARKETED
- Route(s)
- OTIC
- Pharmaceutical form(s)
- SUSPENSION
- Ingredients
- CLOTRIMAZOLE (10 MG), MARBOFLOXACIN (3 MG), DEXAMETHASONE (DEXAMETHASONE ACETATE) (0.9 MG)
- Species (DPD record)
- DOGS
- Company
- VETOQUINOL N A INC (DIN owner)
Source and provenance
- Source dataset
- health_canada_dpd_marketed
- Source snapshot date
- Not available in this source
- Source record key
- 83919
- Archive fingerprint (SHA-256)
- 85cc3ce208af3aa57018c3d14d83f90220c436baef7455384b6d48d9774e1c88
Linked clinical reference
Clinical entries are linked through the active molecule. Check their species, formulation, source and review status separately from this product record.
Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications4
Anti-inflammatory, immunosuppressive, diagnostic (ACTH suppression testing)
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Anti-inflammatory, immunosuppressive, diagnostic (ACTH suppression testing) — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Anti-inflammatory, immunosuppressive, diagnostic (ACTH suppression testing) — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Skin/soft tissue, bone, UTI, pneumonia, intracellular organisms (Mycoplasma haemofelis)
DogCatOn-label (ON_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Skin/soft tissue, bone, UTI, pneumonia, intracellular organisms (Mycoplasma haemofelis) — Authorized (FDA)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Skin/soft tissue, bone, UTI, pneumonia, intracellular organisms (Mycoplasma haemofelis) — Authorized (FDA)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens15
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Select a species above to calculate a dose.
Adverse effects608
PU/PD/PP, GI ulceration, hepatopathy — With sustained use
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
GI bleeding/colonic perforation — Documented risk in canine neurosurgical/spinal patients given high-dose dexamethasone
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hypotension, hemolysis, collapse (rapid IV of PEG-based solution) — Avoidable with slow administration/correct formulation
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
GI (nausea, vomiting, diarrhea), decreased activity — Occasional
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cartilage/articular injury — Young dogs (4–28 wk) and cats (8 mo, high doses 17–28 mg/kg x 42 days)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Deafness2,043 reports
- Vomiting966 reports
- Lethargy (see also Central nervous system depression in 'Neurological')616 reports
- Temporary deafness486 reports
- Diarrhoea412 reports
- Partial deafness373 reports
- Anaphylaxis365 reports
- Death337 reports
- Loss of hearing325 reports
- PR-EAR(S), LESION(S)321 reports
- Other abnormal test result NOS308 reports
- Death by euthanasia302 reports
Cat
- Lethargy (see also Central nervous system depression in 'Neurological')275 reports
- Vomiting254 reports
- Anorexia202 reports
- Death by euthanasia158 reports
- Ataxia155 reports
- Death140 reports
- Lethargy (see also Central nervous system depression in Neurological)139 reports
- Not eating137 reports
- Fever135 reports
- Weight loss130 reports
- Other abnormal test result NOS124 reports
- Elevated alanine aminotransferase (ALT)118 reports
Monitoring2
Clinical signs, liver enzymes, glucose, electrolytes; GI signs specifically given bleeding/perforation risk in high-dose/spinal patients
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Clinical efficacy, adverse effect signs
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications2
Systemic fungal infection (unless Addison's replacement); IM in idiopathic thrombocytopenia
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Fluoroquinolone hypersensitivity; food-producing animals (US)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions7
Diabetic/cardiovascular-risk patients (potent hyperglycemic effect); causes more GI complications/bleeding than prednisone — prefer prednisone/prednisolone when high-dose steroid needed unless dexamethasone specifically indicated
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Documented higher risk of GI bleeding and colonic perforation than prednisone/prednisolone in canine neurosurgical/spinal cord trauma patients — limit dose and duration in these cases, or use prednisone/prednisolone instead where clinically appropriate.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Current evidence does not support high-dose "shock dose" steroids for CNS trauma, spinal injury, or septic shock — avoid this outdated practice.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Confirm which formulation (sodium phosphate vs. PEG-based solution) is on hand before choosing IV administration.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Young/growing animals (cartilage injury risk); seizure-prone patients
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions8
NSAIDs — ↑ GI ulceration/bleeding risk — avoid combination
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Ketoconazole, azole antifungals, macrolides — ↓ dexamethasone metabolism, ↑ levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Phenobarbital, phenytoin, rifampin — ↑ dexamethasone metabolism, ↓ levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cyclosporine — Mutual ↑ blood levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Insulin — ↑ requirement
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics8
Potency — ~30x hydrocortisone; negligible mineralocorticoid activity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — ~2–5h (plasma)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Hepatic
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Bioavailability — ~94% (dog); near-complete (cat)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — Low
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations2
May induce parturition in large animals late in pregnancy. Papich class C — use cautiously.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 367–369; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 217–219 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Safety not established.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 754–757; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 471–473 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references46
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Immune-pathological response induced by Saprolegnia parasitica in Pangasianodon hypophthalmus and assessment of clinical efficacy of clotrimazole.
Study summary not available in the imported record. Open the original citation to review the study.
- Population pharmacokinetics, in-feed bioavailability and tissue depletion of imidazole antifungal clotrimazole in Pangasianodon hypophthalmus.
Study summary not available in the imported record. Open the original citation to review the study.
- Guava Leaf Extract as a Sustainable Preservative Alternative in Semi-Solid Pharmaceuticals: Efficacy and Stability Assessment.
Study summary not available in the imported record. Open the original citation to review the study.
- Clotrimazole disrupts ergosterol biosynthesis and cell membrane integrity via targeting sterol 14α-demethylases to suppress virulence of Magnaporthe oryzae.
Study summary not available in the imported record. Open the original citation to review the study.
- Hydrophobic drug particles adopt a complex biomolecular corona in ex vivo gastrointestinal fluids.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.