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Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications4
Adjunct for liver disease: chronic hepatitis, feline hepatic lipidosis, cholangiohepatitis/triad disease, vacuolar hepatopathy
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Adjunct for liver disease: chronic hepatitis, feline hepatic lipidosis, cholangiohepatitis/triad disease, vacuolar hepatopathy — Nutraceutical
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Adjunct for liver disease: chronic hepatitis, feline hepatic lipidosis, cholangiohepatitis/triad disease, vacuolar hepatopathy — Nutraceutical
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Acute hepatotoxin injury (acetaminophen, xylitol); patients on chronic hepatotoxic drugs (e.g., anticonvulsants)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Acute hepatotoxin injury (acetaminophen, xylitol); patients on chronic hepatotoxic drugs (e.g., anticonvulsants) — Nutraceutical
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Osteoarthritis / cognitive dysfunction support (human depression use)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Osteoarthritis / cognitive dysfunction support (human depression use) — Nutraceutical
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens3
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects180
Well tolerated — Main experience
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Occasional GI upset / vomiting — Possible, reduced by empty-stomach dosing with water
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Elevated alanine aminotransferase (ALT)248 reports
- Elevated serum alkaline phosphatase (SAP)195 reports
- Vomiting184 reports
- Anorexia145 reports
- Elevated total bilirubin145 reports
- Lethargy (see also Central nervous system depression in 'Neurological')142 reports
- Elevated liver enzymes130 reports
- Other abnormal test result NOS93 reports
- Abnormal ultrasound finding92 reports
- Weight loss83 reports
- Death by euthanasia80 reports
- Diarrhoea73 reports
Cat
- Anorexia9 reports
- Lethargy (see also Central nervous system depression in 'Neurological')8 reports
- Vomiting7 reports
- Death by euthanasia4 reports
- Other abnormal test result NOS4 reports
- Death3 reports
- Elevated alanine aminotransferase (ALT)3 reports
- Behavioural disorder NOS2 reports
- Diarrhoea2 reports
- Elevated blood urea nitrogen (BUN)2 reports
- Elevated liver enzymes2 reports
- Elevated total bilirubin2 reports
Monitoring1
Liver enzymes, bilirubin, bile acids (expect 1–4 months before lab changes); clinical appetite/attitude; GSH levels research-only
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Unregulated nutraceutical — use proven-bioavailability products; no FDA efficacy standards
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Empty stomach is the rule — food markedly reduces absorption; give ≥1 hour before feeding with a small water/food treat to speed gastric transit.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The detox rationale: liver disease depletes glutathione; exogenous SAMe restores hepatic (and RBC) GSH — basis for use in acetaminophen/xylitol toxicity alongside NAC.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Keep the B-vitamin cofactors in mind (folate/B12/B6 needed for the SAMe→GSH step) — deficient patients may need supplementation for full effect.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
In acetaminophen toxicity SAMe is second-line/adjunct to N-acetylcysteine, not a replacement.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions1
Serotonergic drugs (human antidepressant co-use) — Theoretical additive serotonin effects (human)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics2
Chemistry — Endogenous molecule (methionine + ATP via SAMe synthetase — hepatic, rate-limiting in liver disease)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pathways — Transmethylation (methyl donor), aminopropylation (polyamines → regeneration), transulfuration → glutathione
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
No specific contraindication data; generally regarded as well tolerated.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1051–1052 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Sources: openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.