Isoflupredone acetate

What is this medication for?

• Potent anti-inflammatory/immunosuppressive: ketosis (cattle), musculoskeletal/inflammatory conditions, shock adjuncts (per label and clinical use)

How is it given?

Give exactly as your veterinarian prescribed — never change the dose or stop on your own unless your veterinarian has told you to.

What if I miss a dose?

• Give it as soon as you remember — unless it is almost time for the next dose (then skip the missed one; never double up).
• Call your clinic if you miss more than one dose in a row.

Side effects — what should I watch for?

Effects listed as common in this handout

• Hypokalemia → recumbency (repeat doses in cattle) (The signature adverse event)
• Local tissue reaction (Injection-site)

Worth a phone call to your veterinarian

• Glucocorticoid class: immunosuppression, PU/PD, steroid hepatopathy, laminitis risk (horses) (Class set)

⚠️ Contact your veterinarian or an emergency clinic IMMEDIATELY if you notice

• Trouble breathing, collapse, seizures, severe vomiting or diarrhea, facial swelling, or pale gums

Before starting (or refilling), tell your veterinarian if your pet:

• has or has had: Systemic fungal infection; label contraindications per species
• has or has had: Cattle: K+ monitoring on repeat dosing (the recumbency syndrome); horses: laminitis predisposition; withdraw-taper after chronic use

• is pregnant, nursing, or used for breeding
• is taking any other medications, supplements, or flea/tick products, including:
  • NSAIDs (flunixin/phenylbutazone)
  • Insulin/diabetics
  • K+-losing diuretics

Storage and handling

Standard injectable storage; food-animal withdrawal rules.

Good to know

• The Predef recumbency story: a "steroid" that behaves like an aldosterone cousin — cows dosed repeatedly go down from hypokalemia, not from the underlying disease; check K+ before blaming the ketosis.
• The steroid+NSAID stacking ban is doubled in large animals where flunixin/bute co-prescription temptations run high.
• Dexamethasone remains the titratable modern choice — Predef's niche is the label convenience + depot-style duration in food animals.