MDose · Veterinary drug reference
ISOFLUPREDONE
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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications3
Potent anti-inflammatory/immunosuppressive: ketosis (cattle), musculoskeletal/inflammatory conditions, shock adjuncts (per label and clinical use)
DogHorseCattleOn-label (ON_LABEL)3 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Potent anti-inflammatory/immunosuppressive: ketosis (cattle), musculoskeletal/inflammatory conditions, shock adjuncts (per label and clinical use) — Authorized (label species/indications)
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Potent anti-inflammatory/immunosuppressive: ketosis (cattle), musculoskeletal/inflammatory conditions, shock adjuncts (per label and clinical use) — Authorized (label species/indications)
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Potent anti-inflammatory/immunosuppressive: ketosis (cattle), musculoskeletal/inflammatory conditions, shock adjuncts (per label and clinical use) — Authorized (label species/indications)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens3
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects195
Hypokalemia → recumbency (repeat doses in cattle) — The signature adverse event
CattleNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Glucocorticoid class: immunosuppression, PU/PD, steroid hepatopathy, laminitis risk (horses) — Class set
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Local tissue reaction — Injection-site
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Polydipsia36 reports
- Polyuria31 reports
- Diarrhoea26 reports
- Vomiting21 reports
- Lethargy (see also Central nervous system depression in 'Neurological')18 reports
- Other abnormal test result NOS14 reports
- Emesis13 reports
- Leucocytosis NOS13 reports
- Panting13 reports
- Anorexia11 reports
- Decreased appetite10 reports
- Elevated alanine aminotransferase (ALT)10 reports
Cat
- Application site alopecia4 reports
- Application site scab3 reports
- Accidental exposure2 reports
- Anorexia2 reports
- Application site bleeding2 reports
- Application site pruritus2 reports
- Application site sore2 reports
- Application site ulcer2 reports
- Ataxia2 reports
- Death2 reports
- Depression2 reports
- Hyperglycaemia2 reports
Monitoring1
Potassium (cattle on repeat dosing), glucose, laminitis watch (horses), injection sites, taper planning
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Systemic fungal infection; label contraindications per species
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Cattle: K+ monitoring on repeat dosing (the recumbency syndrome); horses: laminitis predisposition; withdraw-taper after chronic use
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The Predef recumbency story: a "steroid" that behaves like an aldosterone cousin — cows dosed repeatedly go down from hypokalemia, not from the underlying disease; check K+ before blaming the ketosis.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The steroid+NSAID stacking ban is doubled in large animals where flunixin/bute co-prescription temptations run high.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Dexamethasone remains the titratable modern choice — Predef's niche is the label convenience + depot-style duration in food animals.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
K+-losing diuretics — Additive hypokalemia
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
NSAIDs (flunixin/phenylbutazone) — Additive GI/renal steroid+NSAID toxicity — classic large-animal trap
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Insulin/diabetics — Antagonism
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics2
Mechanism — Long-acting potent glucocorticoid (dexamethasone-intensity class) with mineralocorticoid activity (unlike dex) → the electrolyte story
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
K+-wasting signature — Hypokalemia risk in cattle — recumbency after repeat doses (the documented Predef problem)
CattleNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Glucocorticoid class: fetal/maternal risks + abortion risk near term (cattle label cautions).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 666–668 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references14
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Evaluation of exogenous glucocorticoid injection on preweaning growth performance of neonatal pigs under commercial conditions.
Study summary not available in the imported record. Open the original citation to review the study.
- Characterization of intramuscular Isoflupredone acetate in horses: pharmacokinetics and effects on anti-inflammatory mediators and plasma electrolytes.
Study summary not available in the imported record. Open the original citation to review the study.
- Pharmacokinetics and pharmacodynamics of intra-articular isoflupredone following administration to horses with lipopolysaccharide-induced synovitis.
Study summary not available in the imported record. Open the original citation to review the study.
- In vitro effects of three equimolar concentrations of methylprednisolone acetate, triamcinolone acetonide, and isoflupredone acetate on equine articular tissue cocultures in an inflammatory environment.
Study summary not available in the imported record. Open the original citation to review the study.
- Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.