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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications1
Sedation + analgesia (procedures, restraint); colic analgesia (with masking caution); pre-anesthesia; GKD triple-drip component
HorseOn-label (ON_LABEL)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Sedation + analgesia (procedures, restraint); colic analgesia (with masking caution); pre-anesthesia; GKD triple-drip component — Authorized (label)
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens3
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects107
Bradycardia, AV block, ↓RR, ataxia — Class physiology
HorseNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Sweating, penile prolapse (class) — Occasional
HorseNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Accidental exposure24 reports
- Bradycardia13 reports
- Sedation11 reports
- Pale mucous membrane5 reports
- Sedation prolonged5 reports
- Depression4 reports
- Intentional misuse4 reports
- Tachypnoea4 reports
- Fever3 reports
- No sign3 reports
- Death2 reports
- Diarrhoea2 reports
Cat
- Accidental exposure3 reports
- Abnormal breathing2 reports
- Bradycardia2 reports
- Hyperthermia2 reports
- Sedation prolonged2 reports
- Agitation1 reports
- Apnoea1 reports
- Bradypnoea1 reports
- Cardiac arrest1 reports
- Convulsion1 reports
- Depression1 reports
- Dilated pupils1 reports
Monitoring1
HR/rhythm (class bradycardia), RR, sedation depth; colic patients: monitoring despite the mask
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Heart block; severe coronary/cerebrovascular/respiratory disease; chronic renal failure
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Endotoxic/traumatic shock; advanced hepatic/renal; stress (temperature/fatigue/altitude); impactions; colic patients — masks pain AND cardiopulmonary changes
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The TMPS-fatality warning is the single most-cited detomidine interaction in equine practice: never follow α2 sedation with IV trimethoprim-sulfa.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
µg/kg discipline: 20–40 µg = 0.02–0.04 mg — the mg-confusion is a thousandfold overdose (Plumb bolds this in the source).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Vs xylazine: longer, deeper, potent — pick by duration needed; both reversed by atipamezole.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions4
IV potentiated sulfonamides (TMPS) — FATAL dysrhythmias — manufacturer's explicit warning (α2 + TMPS is the classic lethal pair)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Other CNS depressants/anesthetics — Additive (deliberate combos)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Atropine — Bradyarrhythmia management
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Atipamezole/yohimbine — Reversal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics2
Mechanism — α2-agonist — more potent and longer-acting than xylazine (dose in µg vs mg)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Duration — Profound sedation; bradycardia/AV-block physiology like the class
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Class: late-pregnancy caution (uterine effects).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 364–367 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references16
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Influence of adding detomidine to a lidocaine paravertebral anaesthesia on cytokines and chemokines in cows undergoing laparotomy.
Study summary not available in the imported record. Open the original citation to review the study.
- The Early Ophthalmic Effects of Vatinoxan in Healthy Detomidine-Sedated Horses.
Study summary not available in the imported record. Open the original citation to review the study.
- Investigating the effect of surface cryotherapy on equine patient compliance to infraorbital nerve block placement.
Study summary not available in the imported record. Open the original citation to review the study.
- Exposure to Subcutaneously Administered Butorphanol in Horses Pre-Treated With Detomidine or Detomidine-Vatinoxan.
Study summary not available in the imported record. Open the original citation to review the study.
- Tachycardia and muscle tremors following intravenous administration of detomidine to a horse undergoing standing surgery.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.