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Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
No clinical assertions recorded for an overview.
View full clinical evidence and sources ↓Clinical evidence
Dose regimens0
No dose regimens recorded for this species selection.
Adverse effects200
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting3,201 reports
- Diarrhoea1,543 reports
- Other abnormal test result NOS827 reports
- Lack of efficacy (ectoparasite) - tick NOS755 reports
- Lack of efficacy (bacteria) - Borrelia706 reports
- Seizure NOS695 reports
- Lethargy (see also Central nervous system depression in 'Neurological')625 reports
- Lethargy (see also Central nervous system depression in Neurological)596 reports
- Lack of efficacy (endoparasite) - heartworm538 reports
- Behavioural disorder NOS497 reports
- Lack of efficacy (ectoparasite) - flea494 reports
- Not eating439 reports
Cat
- Vomiting149 reports
- Lack of efficacy (ectoparasite) - flea143 reports
- Panting102 reports
- Behavioural disorder NOS96 reports
- Lethargy (see also Central nervous system depression in Neurological)80 reports
- Scratching65 reports
- Hyperactivity54 reports
- Not eating53 reports
- Itching47 reports
- Vocalisation45 reports
- Pruritus42 reports
- Lethargy (see also Central nervous system depression in 'Neurological')41 reports
Literature references14
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Oral lotilaner in 21 cats with naturally acquired harvest mite infestation.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy of Credelio Quattro™ chewable tablets containing lotilaner, moxidectin, pyrantel, and praziquantel against Ctenocephalides felis and Rhipicephalus sanguineus infestations on dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy of a novel chewable tablet (Credelio Quattro™) containing lotilaner, moxidectin, praziquantel, and pyrantel for the prevention of heartworm disease (Dirofilaria immitis) in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Long-term safety of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets), a novel orally administered combination endectocide for dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy of Credelio Quattro™ (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) and Credelio™ (lotilaner) chewable tablets in the prevention of Borrelia burgdorferi transmission from infected Ixodes scapularis in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.