MDose · Veterinary drug reference
PYRANTEL PAMOATE
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Ascarids (Toxocara canis, T. leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), Physaloptera
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Ascarids (Toxocara canis, T. leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), Physaloptera — Labeled
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Same parasite spectrum — used off-label but considered safe/effective
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Same parasite spectrum — used off-label but considered safe/effective — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects204
Adverse effects unlikely at recommended doses — —
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Emesis (occasional) — Uncommon
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting20,308 reports
- Lack of efficacy (endoparasite) - hookworm8,678 reports
- Diarrhoea8,038 reports
- Lack of efficacy (endoparasite) - heartworm7,065 reports
- Lack of efficacy (bacteria) - Borrelia6,120 reports
- Lethargy (see also Central nervous system depression in 'Neurological')5,336 reports
- Seizure NOS4,924 reports
- Digestive tract disorder NOS4,876 reports
- INEFFECTIVE, HEARTWORM LARVAE4,673 reports
- Lack of efficacy (endoparasite) - roundworm NOS3,569 reports
- Lack of efficacy (ectoparasite) - tick NOS3,028 reports
- Lack of efficacy (endoparasite) - tapeworm3,009 reports
Cat
- Ataxia262 reports
- Vomiting207 reports
- Anorexia119 reports
- Depression117 reports
- Lethargy (see also Central nervous system depression in 'Neurological')102 reports
- Death93 reports
- Diarrhoea90 reports
- Fever64 reports
- Accidental exposure61 reports
- Hypersalivation48 reports
- Emesis39 reports
- Weight loss39 reports
Monitoring1
Follow-up fecal exam 2–4 weeks after treatment to assess need for retreatment
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Use with caution in severely debilitated animals
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
None major
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Core component of standard puppy/kitten deworming protocols (starting as early as 2–3 weeks of age) due to its excellent safety margin.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Frequently combined with praziquantel (Drontal) to add cestode coverage — confirm which combination product is in use when reviewing a patient's deworming history.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
A. caninum resistance to pyrantel has been reported — consider this in cases of apparent treatment failure with recurring hookworm burdens.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Levamisole, morantel — Similar mechanism/toxicity — do not use concurrently
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Piperazine — Antagonistic mechanism of action — do not combine
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Diethylcarbamazine, organophosphates — ↑ risk of adverse (cholinergic-type) effects
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics2
Absorption — Poorly absorbed (pamoate salt) — intentional, keeps drug concentrated in GI lumen
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Absorbed fraction rapidly metabolized, excreted urine/feces
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Considered safe in pregnant/nursing patients. Human FDA category C. Papich class A. Safe in nursing veterinary patients per Plumb's.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references6
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Assessment of the antiparasitic effectiveness of pyrantel pamoate in treatment of Strongylidae invasions in young horses - preliminary studies.
Study summary not available in the imported record. Open the original citation to review the study.
- Effectiveness of Anthelmintic Therapy and Determinants of Ascaris lumbricoides Infection among School-Aged Children: A Community-Based Cross-Sectional Study in Rural Khyber Pakhtunkhwa, Pakistan.
Study summary not available in the imported record. Open the original citation to review the study.
- Treatment and control of Haemaphysalis longicornis infestations on dogs using a formulation of sarolaner, moxidectin and pyrantel (Simparica Trio®).
Study summary not available in the imported record. Open the original citation to review the study.
- Successful treatment of Trypanoxyuris sp. infection in naturally infected southern brown-howlers (Alouatta guariba clamitans).
Study summary not available in the imported record. Open the original citation to review the study.
- Safety of an oral combination of moxidectin, afoxolaner, and pyrantel pamoate in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.