Regulatory product record
DOLPAC 25
Product identity, ingredients and source provenance from the regulatory catalogue. Linked clinical evidence has a separate review status.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Product identity
- Brand name
- DOLPAC 25
- DIN
- 02328291
- DPD drug code
- 81382
- Regulatory category
- APPROVED_VET_DRUG
- Market status
- MARKETED
- Route(s)
- ORAL
- Pharmaceutical form(s)
- TABLET
- Ingredients
- PRAZIQUANTEL (125.0 MG), OXANTEL PAMOATE (1397.5 MG), PYRANTEL PAMOATE (360.0 MG)
- Species (DPD record)
- DOGS
- Company
- VETOQUINOL N A INC (DIN owner)
Source and provenance
- Source dataset
- health_canada_dpd_marketed
- Source snapshot date
- Not available in this source
- Source record key
- 81382
- Archive fingerprint (SHA-256)
- 85cc3ce208af3aa57018c3d14d83f90220c436baef7455384b6d48d9774e1c88
Linked clinical reference
Clinical entries are linked through the active molecule. Check their species, formulation, source and review status separately from this product record.
Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications4
Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus (and E. multilocularis)
DogOn-label (ON_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus (and E. multilocularis) — FDA-approved (labeled)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dipylidium caninum, Taenia taeniaeformis
CatOn-label (ON_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Dipylidium caninum, Taenia taeniaeformis — FDA-approved (labeled)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Ascarids (Toxocara canis, T. leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), Physaloptera
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Ascarids (Toxocara canis, T. leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), Physaloptera — Labeled
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Same parasite spectrum — used off-label but considered safe/effective
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Same parasite spectrum — used off-label but considered safe/effective — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens10
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Select a species above to calculate a dose.
Adverse effects409
Uncommon overall (oral use) — <5% (dog), <2% (cat)
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Anorexia, vomiting, lethargy, diarrhea (oral) — Uncommon
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pain at injection site, drowsiness, staggering gait (injectable) — More common than with oral form
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Salivation, diarrhea, weakness, transient anorexia (injectable) — ~9.4% of cats in field trials
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Adverse effects unlikely at recommended doses — —
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting20,308 reports
- Vomiting15,638 reports
- Lack of efficacy (endoparasite) - heartworm8,774 reports
- Lack of efficacy (endoparasite) - hookworm8,678 reports
- Diarrhoea8,038 reports
- Lack of efficacy (endoparasite) - heartworm7,065 reports
- Lack of efficacy (bacteria) - Borrelia6,120 reports
- Diarrhoea5,549 reports
- Lethargy (see also Central nervous system depression in 'Neurological')5,336 reports
- Seizure NOS4,924 reports
- Digestive tract disorder NOS4,876 reports
- INEFFECTIVE, HEARTWORM LARVAE4,673 reports
Cat
- Hypersalivation1,636 reports
- Vomiting1,595 reports
- Application site alopecia1,497 reports
- Ataxia1,224 reports
- Lethargy (see also Central nervous system depression in 'Neurological')1,052 reports
- Lack of efficacy (endoparasite) - tapeworm906 reports
- Anorexia724 reports
- Behavioural disorder NOS694 reports
- Lethargy (see also Central nervous system depression in Neurological)642 reports
- Diarrhoea541 reports
- Application site hair loss514 reports
- Foaming at the mouth485 reports
Monitoring2
Fecal exam to confirm efficacy; reinfection is common with D. caninum given ongoing flea exposure — counsel concurrent flea control
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Follow-up fecal exam 2–4 weeks after treatment to assess need for retreatment
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications2
Manufacturer: avoid in puppies <4 weeks or kittens <6 weeks (though praziquantel/febantel combo is approved for all ages); hypersensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Use with caution in severely debilitated animals
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions8
None major beyond age restriction on monotherapy product
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Not effective against most nematodes (roundworms, hookworms) on its own — combination products (Drontal, etc.) exist specifically to broaden spectrum; confirm which product a client is using before assuming coverage.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Wide margin of safety — one of the best-tolerated anthelmintics in the antiparasitic library.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
D. caninum reinfection is essentially guaranteed without concurrent flea control, since fleas serve as the intermediate host — pair prescription with a flea-control conversation.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
None major
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions4
Grapefruit juice — ↑ praziquantel AUC 150–200% in dogs (avoid coadministration if practical)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Levamisole, morantel — Similar mechanism/toxicity — do not use concurrently
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Piperazine — Antagonistic mechanism of action — do not combine
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Diethylcarbamazine, organophosphates — ↑ risk of adverse (cholinergic-type) effects
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Bioavailability — Rapid, near-complete oral absorption but significant first-pass effect
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Hepatic, CYP3A
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Primarily renal (metabolites)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Absorption — Poorly absorbed (pamoate salt) — intentional, keeps drug concentrated in GI lumen
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Absorbed fraction rapidly metabolized, excreted urine/feces
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations2
Considered safe in pregnant dogs/cats and during lactation. Human FDA category B. Papich class A. Excreted in milk (~25% of maternal serum concentration) — unlikely to harm nursing offspring.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 992–994; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 663–664 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Considered safe in pregnant/nursing patients. Human FDA category C. Papich class A. Safe in nursing veterinary patients per Plumb's.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1024–1026; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 693–694 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references19
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug.
Study summary not available in the imported record. Open the original citation to review the study.
- Safranal Enhances the Efficacy of Praziquantel Against Schistosoma mansoni Infection and Alleviates Liver Fibrosis, Inflammation and Oxidative Stress in Mice.
Study summary not available in the imported record. Open the original citation to review the study.
- Reinfection dynamics of owned dogs with Echinococcus granulosus sensu lato in endemic rural areas of central Iran: Implications for cystic echinococcosis control.
Study summary not available in the imported record. Open the original citation to review the study.
- The therapeutic potential of green synthesized zinc oxide nanoparticles in murine schistosomiasis.
Study summary not available in the imported record. Open the original citation to review the study.
- Plant-derived anthelmintic agents in veterinary helminth control: Mechanistic insights and translational challenges.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.