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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications1
Prevention of NSAID (esp. aspirin)-induced GI ulceration; adjunct for atopic dermatitis (modest efficacy); reproductive uses (pregnancy termination, pyometra adjunct)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Prevention of NSAID (esp. aspirin)-induced GI ulceration; adjunct for atopic dermatitis (modest efficacy); reproductive uses (pregnancy termination, pyometra adjunct) — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens3
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects104
GI distress (diarrhea, abdominal pain, vomiting, flatulence) — Most common
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Uterine contractions, vaginal bleeding — Possible in intact females
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting24 reports
- Death by euthanasia20 reports
- Lethargy (see also Central nervous system depression in 'Neurological')20 reports
- Elevated alanine aminotransferase (ALT)17 reports
- Anorexia16 reports
- Elevated serum alkaline phosphatase (SAP)16 reports
- Anaemia NOS15 reports
- Diarrhoea15 reports
- Other abnormal test result NOS13 reports
- Hypoalbuminaemia11 reports
- Elevated blood urea nitrogen (BUN)10 reports
- Elevated creatinine10 reports
Cat
- Glucosuria1 reports
- Seizure NOS1 reports
Monitoring1
Clinical efficacy; GI tolerance
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Pregnancy (abortifacient) — even accidental human exposure is a concern; pregnant women should handle with extreme care
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Cerebral/coronary vascular disease; prostaglandin sensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnant women in the household should not handle this medication — significant abortifacient/human health risk from accidental exposure; make this an explicit client-counseling point.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Efficacy specifically demonstrated for aspirin-induced GI injury — not proven effective against corticosteroid-induced GI injury, and other NSAIDs less well studied.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Used in specific reproductive protocols (pregnancy termination, pyometra adjunct with aglepristone) — a specialist-level use, not routine.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions1
Magnesium-containing antacids — May worsen misoprostol-induced diarrhea — use aluminum-only antacid if needed
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Bioavailability — ~88% absorbed, significant first-pass metabolism
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — ~90% (parent and active acid metabolite)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — ~30 min (human)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — De-esterified to active misoprostol acid, then oxidative inactivation
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Renal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Contraindicated in pregnancy — abortifacient. Human FDA category X. Papich canine/feline class D (contraindicated). Not known to enter milk in parent form; not recommended in nursing mothers (diarrhea risk in offspring).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 849–851; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 537–538 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references19
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Pharmacological reduction of neutrophil infiltration reduces Clostridioides difficile infection severity.
Study summary not available in the imported record. Open the original citation to review the study.
- Comprehensive Overview of Methods of Pregnancy Termination in Macaques and Marmosets.
Study summary not available in the imported record. Open the original citation to review the study.
- Does lesion type or severity predict outcome of therapy for horses with equine glandular gastric disease? - A retrospective study.
Study summary not available in the imported record. Open the original citation to review the study.
- Protective potential of misoprostol against kidney alteration via alleviating oxidative stress in rat following exposure to paclitaxel.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of a single dose of orally and rectally administered misoprostol in an in vivo endotoxemia model in healthy adult horses.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.