MDose · Veterinary drug reference
TULATHROMYCIN
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications6
BRD (Mannheimia/Pasteurella/Histophilus), infectious bovine keratoconjunctivitis (label); ovine respiratory disease
CattleOn-label (ON_LABEL)1 source record · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: BRD (Mannheimia/Pasteurella/Histophilus), infectious bovine keratoconjunctivitis (label); ovine respiratory disease — Authorized (label)
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Respiratory disease (label)
SwineOn-label (ON_LABEL)1 source record · View provenance
- Swine · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Respiratory disease (label) — Authorized
- Swine · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
INDICATIONS Swine Actinobacillus pleuropneumoniae Pasteurella multocida Bordetella bronchiseptica Haemophilus parasuis Mycoplasma hyopneumoniae Actinobacillus pleuropneumoniae Pasteurella multocida Mycoplasma hyopneumoniae RESPIRmycin 25 Injectable Solution is indicated for the treatment of swine respiratory disease (SRD) associated with,,,, and; and for the control of SRD associated with,, andin groups of pigs where SRD has been diagnosed. Suckling Calves, Dairy Calves, and Veal Calves BRD Mannheimia haemolytica Pasteurella multocida Histophilus somni Mycoplasma bovis – RESPIRmycin 25 Injectable Solution is indicated for the treatment of bovine respiratory disease (BRD) associated with,,, and.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Swine Actinobacillus pleuropneumoniae, Pasteurella multocida, Bordetella bronchiseptica, Haemophilus parasuis, Mycoplasma hyopneumoniae Actinobacillus pleuropneumoniae, Pasteurella multocida, Mycoplasma hyopneumoniae Increxxa 25 Injectable Solution is indicated for the treatment of swine respiratory disease (SRD) associated withand; and for the control of SRD associated withandin groups of pigs where SRD has been diagnosed. Suckling Calves, Dairy Calves, and Veal Calves BRD - Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, Mycoplasma bovis Increxxa 25 Injectable Solution is indicated for the treatment of bovine respiratory disease (BRD) associated withand.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
INDICATIONS Swine Actinobacillus pleuropneumoniae Pasteurella multocida Bordetella bronchiseptica Haemophilus parasuis Mycoplasma hyopneumoniae Actinobacillus pleuropneumoniae Pasteurella multocida Mycoplasma hyopneumoniae VACASAN™ 25 Injectable Solution is indicated for the treatment of swine respiratory disease (SRD)associated with,,,, and; and for the control of SRD associated with,, andin groups ofpigs where SRD has been diagnosed. Suckling Calves, Dairy Calves, and Veal Calves BRD Mannheimia haemolytica Pasteurella multocida Histophilus somni Mycoplasma bovis – VACASAN 25 Injectable Solution is indicated for the treatment of bovine respiratory disease (BRD) associated with,,, and.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens10
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
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Adverse effects74
Injection-site reactions — Most likely adverse effect
CattleSwineNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Swine · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Occasional anorexia/transient signs — Label events
CattleNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cattle In one BRD field study, two calves treated with DRAXXIN at 2.5 mg/kg BW exhibited transient hypersalivation. One of these calves also exhibited transient dyspnea, which may have been related to pneumonia. Swine In one field study, one out of 40 pigs treated with DRAXXIN at 2.5 mg/kg BW exhibited mild salivation that resolved in less than four hours.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Cattle In one BRD field study, two calves treated with tulathromycin injection at 2.5 mg/kg BW exhibited transient hypersalivation. One of these calves also exhibited transient dyspnea, which may have been related to pneumonia. Swine In one field study, one out of 40 pigs treated with tulathromycin injection at 2.5 mg/kg BW exhibited mild salivation that resolved in less than four hours.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Repeated administration of NSAIDs can result in gastric or renal toxicity. Sensitivity to drug-associated adverse effects varies with the individual patient. Patients at greatest risk for toxicity are those that are dehydrated, on concomitant diuretic therapy, or those with pre-existing gastric ulcers, renal, cardiovascular, and/or hepatic dysfunction.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Injection site reaction NOS2 reports
- Injection site swelling2 reports
- Lack of efficacy (bacteria) - NOS2 reports
- No sign2 reports
- Agglutination test, positive1 reports
- Abnormal pupil light reflex1 reports
- Accidental exposure1 reports
- Blindness1 reports
- Coughing up blood1 reports
- Cutaneous emphysema1 reports
- Death1 reports
- Decreased packed cell volume (PCV)1 reports
Cat
- Blindness3 reports
- Neurological signs NOS3 reports
- Vocalisation3 reports
- Ataxia2 reports
- Death2 reports
- Elevated alanine aminotransferase (ALT)2 reports
- Elevated aspartate aminotransferase (AST)2 reports
- Elevated blood urea nitrogen (BUN)2 reports
- Head bobbing2 reports
- Hypothermia2 reports
- Lack of efficacy - NOS2 reports
- Anaemia NOS1 reports
Monitoring1
Clinical response (one shot = no re-dosing decisions unless relapse); injection sites; withdrawal periods
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications11
Hypersensitivity; lactating dairy/veal (label)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The use of DRAXXIN KP Injection is contraindicated in animals previously found to be hypersensitive to tulathromycin and ketoprofen.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
The use of DRAXXIN 25 Injectable Solution is contraindicated in animals previously found to be hypersensitive to the drug.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
The use of DRAXXIN Injectable Solution is contraindicated in animals previously found to be hypersensitive to the drug.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
The use of Increxxa Injectable Solution is contraindicated in animals previously found to be hypersensitive to the drug.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Precautions17
Withdrawal compliance; antimicrobial-stewardship context for macrolide-class use in food animals
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics as product design: an 8.75-day lung half-life converts a macrolide into "metaphylaxis in one injection" — the Vd-plus-tissue-binding lesson in commercial form.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Resistance-era honesty: "not a major problem" was true at publication — macrolide stewardship in food animals has tightened since; stewardship framing belongs in the file.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Draxxin vs Nuflor one-shot comparison: both single-visit solutions, different classes — tulathromycin macrolide-kinetics vs florfenicol phenicol-kinetics.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cattle must not be slaughtered for human consumption within 18 days following last treatment with this drug product. Not for use in female dairy cattle 1 year of age or older, including dry dairy cows; use in these cattle may cause drug residues in milk and/or in calves born to these cows or heifers. Not for use in beef calves less than 2 months of age, dairy calves, and veal calves. A withdrawal period has not been established for this product in pre-ruminating calves.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Interactions2
50S competitors (chloramphenicol/lincosamides) — Antagonism (class)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Other macrolides — Redundant
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics18
Mechanism — Triamilide macrolide (50S) — extended-spectrum vs older macrolides
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cattle PK — >90% SC bioavailability; Vd ~11 L/kg; lung-tissue t½ ~8.75 DAYS (plasma 2.75 d) — lung-hugging is the product
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Swine PK — Vd 13–15 L/kg; lung t½ ~5.9 d
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Breakpoints — BRD MIC breakpoints ~2 µg/mL (plasma)/1 (lung) — resistance "not yet a major problem" (era note)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Biliary (cattle)/fecal-urinary (swine), unchanged
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Not for lactating dairy cattle or veal calves (label restriction).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1151–1153 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references12
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Synergistic effect and resistance prevention activity of antimicrobial peptide MPX with Tulathromycin against Actinobacillus pleuropneumoniae.
Study summary not available in the imported record. Open the original citation to review the study.
- Analgesic and antioxidant potential of tulathromycin: evidence from molecular docking, in vitro assay, and in vivo model.
Study summary not available in the imported record. Open the original citation to review the study.
- A novel tulathromycin oil suspension injection: preparation, characterization, and pharmacokinetics in goats.
Study summary not available in the imported record. Open the original citation to review the study.
- The Pharmacokinetics of Tulathromycin Following Subcutaneous Administration in Rhesus Macaques (Macaca mulatta).
Study summary not available in the imported record. Open the original citation to review the study.
- Health outcomes following antimicrobial treatment of septic arthritis in Canadian feedlot calves.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: DailyMed, U.S. National Library of Medicine; PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.