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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications4
For use in dogs for humane, painless, and rapid euthanasia.
DogSpecies not recordedOn-label (ON_LABEL)United States4 source records · View provenance
- Dog · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Dog · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Dog · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Species not recorded · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects156
For inquiries or to report suspected adverse drug experiences, please contact Parnell at 1-800-887-2763 or visit www.parnell.com. For additional information about reporting adverse drug experiences for animal drugs, contact FDA at 1- 888-FDA-VETS or online at www.fda.gov/reportanimalae To obtain a Safety Data Sheet(s), contact Parnell at 1-800-887-2763 or www.parnell.com
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Covetrus® North America at (855) 724-3461 or covetrus.com. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae.
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact the technical help-line at866-489-1344. For additional information about adverse drug experience reporting for animal drugs,contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae.
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- INEFFECTIVE, EUTHANASIA175 reports
- Lack of efficacy - NOS119 reports
- Overdose51 reports
- Death by euthanasia43 reports
- INEFFECTIVE, DELAYED EFFECT38 reports
- Vocalisation30 reports
- Unrelated death18 reports
- Agonal breathing14 reports
- Abnormal breathing10 reports
- Respiratory tract disorder NOS9 reports
- Incorrect route of drug administration8 reports
- Abnormal movement NOS7 reports
Cat
- INEFFECTIVE, EUTHANASIA52 reports
- Lack of efficacy - NOS49 reports
- INEFFECTIVE, DELAYED EFFECT17 reports
- Death by euthanasia11 reports
- Agonal breathing7 reports
- Abnormal breathing6 reports
- Drug administration error6 reports
- Vocalisation6 reports
- Twitching5 reports
- Unrelated death5 reports
- Excitation4 reports
- Abnormal movement NOS3 reports
Precautions8
For canine euthanasia only. Must not be used for therapeutic purposes. Do not use in animals intended for food.
DogSpecies not recordedOn-label (ON_LABEL)United States4 source records · View provenance
- Dog · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Dog · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Dog · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Species not recorded · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Euthanasia may sometimes be delayed in dogs with severe cardiac or circulatory deficiencies. This may be explained by the impaired movement of the drug to its site of action. An occasional dog may elicit reflex responses manifested by motor movement; however, an unconscious animal does not experience pain, because the cerebral cortex is not functioning. When restraint may cause the dog pain, injury, or anxiety, or danger to the person making the injection, prior use of tranquilizing or immobilizing drugs may be necessary.
DogSpecies not recordedOn-label (ON_LABEL)United States4 source records · View provenance
- Dog · SPL section 42232-9 (PRECAUTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Dog · SPL section 42232-9 (PRECAUTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Dog · SPL section 42232-9 (PRECAUTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Species not recorded · SPL section 42232-9 (PRECAUTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Literature references18
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Veterinary euthanasia of dogs and cats in Flanders: an online survey of current practices and perspectives.
Study summary not available in the imported record. Open the original citation to review the study.
- A Comparison of Intravenous and Oral Transmucosal Administration of Pentobarbital Sodium for Humane Euthanasia in White Leghorn Chickens (Gallus gallus domesticus).
Study summary not available in the imported record. Open the original citation to review the study.
- FabG moonlights as an extracellular adhesin mediates cytoadhesion of Streptococcus suis via interaction with plasminogen.
Study summary not available in the imported record. Open the original citation to review the study.
- Combining ATAC-seq and RNA-seq reveals key genes for gonadal abnormalities in one-month-old XX-DSD pigs.
Study summary not available in the imported record. Open the original citation to review the study.
- Euthanasia of canines and felines under anesthesia can be achieved with lidocaine or mepivacaine via intrathecal, intravenous, or intracardiac routes.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: DailyMed, U.S. National Library of Medicine; PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.