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Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Rapid flea adulticide knockdown (kills >99% fleas in 3–6 h); maggot (myiasis) treatment (crushed tablet PO/wound/enema — reptile/exotic source)
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Rapid flea adulticide knockdown (kills >99% fleas in 3–6 h); maggot (myiasis) treatment (crushed tablet PO/wound/enema — reptile/exotic source) — OTC (label); exotic uses extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Rapid flea adulticide knockdown (kills >99% fleas in 3–6 h); maggot (myiasis) treatment (crushed tablet PO/wound/enema — reptile/exotic source) — OTC (label); exotic uses extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects202
Transient itching/scratching as fleas die — Commonly noted behavior
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Occasional vomiting/lethargy/hyperactivity — Rare label events
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Lack of efficacy (ectoparasite) - flea4,757 reports
- Lack of efficacy (flea)1,307 reports
- Vomiting952 reports
- Lethargy (see also Central nervous system depression in 'Neurological')707 reports
- Lack of efficacy - NOS666 reports
- Diarrhoea543 reports
- Pruritus486 reports
- Scratching449 reports
- Anorexia369 reports
- Overdose343 reports
- Depression342 reports
- Itching342 reports
Cat
- Hyperactivity2,198 reports
- Lack of efficacy (ectoparasite) - flea1,835 reports
- Panting1,769 reports
- Vocalisation1,241 reports
- Agitation899 reports
- Scratching715 reports
- Lethargy (see also Central nervous system depression in 'Neurological')567 reports
- Pruritus551 reports
- Vomiting501 reports
- Behavioural disorder NOS465 reports
- Lack of efficacy (flea)455 reports
- Itching421 reports
Monitoring1
Flea knockdown (visible within hours); pruritus transient; re-infestation from environment
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Not effective against eggs/larvae/ticks — never a standalone flea program; pair with IGR (lufenuron) or monthly adulticide
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The 24-hour assassin: fastest kill in the flea arsenal — ideal for new infestations, shelter intake, pre-adoption, or bridging to a monthly product; useless for prevention alone (1–2 day coverage).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Weight-banded tablets (11.4 mg / 57 mg) = dosing by count, not calculation — the OTC-friendly design.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Neonicotinoid selectivity (insect nAChR) is why a cat can eat a tablet that empties its flea load — memorize the 3,500× selectivity line as the species-safety story.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions2
Lufenuron — The classic deliberate pair (adulticide + IGR = Program+Capstar logic)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Other flea products — Generally safe to combine per label
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Neonicotinoid: binds insect nicotinic ACh receptors (post-synaptic) → paralysis/death — 3,500× selectivity for insect α4β2 nAChR vs vertebrate
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Speed/duration — Fleas start falling off ~30 min; near-complete kill 3–6 h; protects only 1–2 days
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Margin — Dog/cat LD50 >10 g/kg
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Label permits use (widely used in breeding/young animals per label era).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 890–891 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references19
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Nitenpyram promotes breast cancer progression via PARP1: Integration of multi-omics analyses with experimental validation.
Study summary not available in the imported record. Open the original citation to review the study.
- Integrated assessment of Nitenpyram-induced physiological and microbial alterations in Chinese longsnout catfish.
Study summary not available in the imported record. Open the original citation to review the study.
- Evaluation of tobacco pesticides nitenpyram-spiroxamine co-exposure effects on honeybees: Molecular mechanisms and melatonin's protective role.
Study summary not available in the imported record. Open the original citation to review the study.
- Pilot study on neonicotinoids in Finnish waterbirds: no detectable concentrations in common goldeneye (Bucephala clangula) plasma.
Study summary not available in the imported record. Open the original citation to review the study.
- A sensitive and specific enzyme-linked immunosorbent assay for the detection of pymetrozine in vegetable, cereal, and meat.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.