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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
IMHA, myasthenia gravis, glomerulonephritis, pemphigus foliaceous — usually when other agents (azathioprine, steroids) fail
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: IMHA, myasthenia gravis, glomerulonephritis, pemphigus foliaceous — usually when other agents (azathioprine, steroids) fail — Extra-label, limited veterinary experience
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
IMHA — very limited case data
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: IMHA — very limited case data — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens2
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects121
Diarrhea, vomiting, anorexia, lethargy — Most common, dose-related (more at 30 mg/kg than 10 mg/kg)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Lymphopenia, increased dermal infection rates — Reported
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Well tolerated at 10 mg/kg q12h — —
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Death by euthanasia33 reports
- Immune mediated haemolytic anaemia27 reports
- Leucocytosis NOS23 reports
- Vomiting23 reports
- Lethargy (see also Central nervous system depression in 'Neurological')20 reports
- Thrombocytopenia19 reports
- Diarrhoea18 reports
- Anaemia NOS17 reports
- Anorexia17 reports
- Lethargy (see also Central nervous system depression in Neurological)17 reports
- Other abnormal test result NOS17 reports
- Neutrophilia16 reports
Cat
- Abdominal effusion1 reports
- Anaemia NOS1 reports
- Anorexia1 reports
- Cardiac enlargement1 reports
- Cardiomyopathy1 reports
- Death1 reports
- Epistaxis1 reports
- Hepatomegaly1 reports
- Hyperphosphataemia1 reports
- Immune mediated haemolytic anaemia1 reports
- Lameness1 reports
- Liver disorder NOS1 reports
Monitoring1
CBC, renal/hepatic function, electrolytes (baseline + periodic); GI tolerance/weight
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Hypersensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Severe renal dysfunction (dose adjustment); IV form must be infused over ≥2h, never bolus
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Give on an empty stomach when possible — switch to with-food dosing only if vomiting/inappetence becomes limiting.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Human labeling carries a black-box lymphoma-risk warning — while veterinary significance is unclear given limited use, factor this into long-term risk discussions with owners.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Reserve for cases where azathioprine or glucocorticoids alone have failed — this is generally a second/third-line agent in current veterinary practice, not first-line.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions4
Antacids (Al/Mg-containing), oral iron — ↓ absorption — separate dosing by ≥2h
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Azathioprine — ↑ bone marrow suppression risk — combination not recommended
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Acyclovir, probenecid, aspirin — ↑ mycophenolic acid levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Live vaccines — Reduced efficacy — avoid
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics4
Bioavailability — Wide inter-patient/inter-dose variability (54–87% across doses in one dog)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — ~45 min parent (dog); active metabolite (MPA) 2.2–8h
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Prodrug → active mycophenolic acid (MPA)
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Renal — ~90% as glucuronide metabolite, ~5% unchanged
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Increased resorptions/malformations in rabbit/rat studies at doses below human therapeutic range — avoid in pregnancy if at all possible. Distributed into rat milk; safety in nursing unknown.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 869–871; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 550–552 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references14
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Treatment of moderate-to-severe canine atopic dermatitis with modified-release mycophenolate (OKV-1001): A pilot open-label, single-arm multicentric clinical trial.
Study summary not available in the imported record. Open the original citation to review the study.
- MMF inhibits poxvirus infection by disrupting IMPDH2 interaction with USP5 and inducing its rod-and-ring assemblies.
Study summary not available in the imported record. Open the original citation to review the study.
- First Case Report of Precursor-Targeted Immune-Mediated Anaemia in a Dog From Italy Lacking Rubriphagocytosis and With Severe Hyperferraemia: Diagnosis, Treatment, and Clinical Outcome.
Study summary not available in the imported record. Open the original citation to review the study.
- Exhausted/senescent CD4(+) T cells as predictors of vaccine failure and severe coronavirus disease 2019 in solid organ transplant recipients.
Study summary not available in the imported record. Open the original citation to review the study.
- Eltrombopag is well tolerated but provides no additional benefit in the treatment of canine primary immune-mediated thrombocytopenia.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.