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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Adjunctive anticonvulsant (with phenobarbital); anxiety/phobia behavior disorders — tolerance develops more slowly than clonazepam
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Adjunctive anticonvulsant (with phenobarbital); anxiety/phobia behavior disorders — tolerance develops more slowly than clonazepam — Extra-label (human drug; C-IV)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Anxiolytic
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Anxiolytic — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects25
Sedation, ataxia — Most prevalent
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Paradoxical excitation — Possible (class)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Seizure NOS5 reports
- Abnormal menace reflex test1 reports
- Addison's disease1 reports
- Behavioural disorder NOS1 reports
- Death by euthanasia1 reports
- Difficulty to rise1 reports
- Drooling1 reports
- Dull1 reports
- Facial swelling (see also 'Skin')1 reports
- Falling1 reports
- Head bobbing1 reports
- Hind limb paresis1 reports
Monitoring1
Seizure diary; sedation; PB levels when combined
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications3
Benzo hypersensitivity, narrow-angle glaucoma, significant liver disease
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Severe liver dysfunction, aggression
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Table 1 (p.630), row: Clorazepate, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
- Cat · Table 1 (p.630), row: Clorazepate, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
Precautions4
Extreme caution in aggressive (esp. fear-induced) animals; myasthenia gravis; phenobarbital interaction (mutual metabolism — monitor levels)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Prodrug pharmacology = slower onset but slower tolerance vs clonazepam's fast-acting fast-fading profile — the trade that defines their different niches.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Not a status-epilepticus drug (conversion takes time) — maintenance adjunct only.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The phenobarbital pairing needs level-checking in both directions.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Phenobarbital — Interaction documented — adjust/monitor
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Other CNS depressants — Additive
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Omeprazole/acid suppression (human) — ↓ prodrug conversion (pH-dependent activation)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics2
Activation — Prodrug — converted (gastric/acidity-dependent, to desmethyldiazepam/nordiazepam)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Tolerance — Slower than clonazepam for anticonvulsant effect
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Avoid (class: teratogenicity reports).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 306–307; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references9
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Animal behavior case of the month. Noise phobia.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of serum separation tubes on serum benzodiazepine and phenobarbital concentrations in clinically normal and epileptic dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of a 44-day administration of phenobarbital on disposition of clorazepate in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Serum disposition of oral clorazepate from regular-release and sustained-delivery tablets in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Disposition of clorazepate in dogs after single- and multiple-dose oral administration.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Perrin C, Seksel K, Landsberg GM. Appendix: Drug Dosage Chart. Vet Clin Small Anim 2014;44:629-632.; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.