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Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
No clinical assertions recorded for an overview.
View full clinical evidence and sources ↓Clinical evidence
Dose regimens0
No dose regimens recorded for this species selection.
Adverse effects146
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Accidental exposure7 reports
- Vomiting4 reports
- Behavioural disorder NOS3 reports
- Anorexia2 reports
- Heart murmur2 reports
- Hypersalivation2 reports
- Incorrect route of drug administration2 reports
- Lack of efficacy (bacteria) - Borrelia2 reports
- Lack of efficacy (endoparasite) - heartworm2 reports
- Lethargy (see also Central nervous system depression in Neurological)2 reports
- Low platelet count2 reports
- Medication error NOS2 reports
Cat
- Lethargy (see also Central nervous system depression in Neurological)486 reports
- Vomiting382 reports
- Application site hair loss275 reports
- Hypersalivation270 reports
- Foaming at the mouth243 reports
- Drooling204 reports
- Lack of efficacy (ectoparasite) - flea199 reports
- Ataxia194 reports
- Not eating189 reports
- Lack of efficacy (endoparasite) - roundworm NOS173 reports
- Lack of efficacy (endoparasite) - tapeworm159 reports
- Accidental exposure152 reports
Literature references13
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Efficacy of a topical combination of esafoxolaner, eprinomectin and praziquantel against Amblyomma maculatum infestations in cats.
Study summary not available in the imported record. Open the original citation to review the study.
- Treatment of notoedric mange with esafoxolaner, eprinomectin and praziquantel in naturally infested cats under in-home conditions.
Study summary not available in the imported record. Open the original citation to review the study.
- Clinical efficacy of a parasiticide formulation containing eprinomectin, esafoxolaner and praziquantel (NexGard® Combo) in the treatment of natural feline aelurostrongylosis and troglostrongylosis.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy of a combination of esafoxolaner, eprinomectin and praziquantel (NexGard(®) Combo) against Thelazia callipaeda in naturally infected cats.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy of a topical formulation containing eprinomectin, esafoxolaner and praziquantel (NexGard(®) Combo) in the treatment of natural respiratory capillariosis of cats.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.