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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Lymphoid/hematopoietic neoplasms (combination protocols — CHOP backbone); transmissible venereal tumor (sole therapy); immune-mediated thrombocytopenia (adjunct — thrombocytosis effect)
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Lymphoid/hematopoietic neoplasms (combination protocols — CHOP backbone); transmissible venereal tumor (sole therapy); immune-mediated thrombocytopenia (adjunct — thrombocytosis effect) — Extra-label (human drug)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Lymphoid/hematopoietic neoplasms (combination protocols — CHOP backbone); transmissible venereal tumor (sole therapy); immune-mediated thrombocytopenia (adjunct — thrombocytosis effect) — Extra-label (human drug)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects116
Peripheral neurotoxicity > vinblastine: proprioceptive deficits, spinal hyporeflexia, paralytic ileus/constipation — Dose/cumulative
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Myelosuppression — Much less than vinblastine
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Stomatitis, alopecia (minimal in dogs/cats), inappropriate ADH secretion — Occasional
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting24 reports
- Death by euthanasia22 reports
- Thrombocytopenia21 reports
- Diarrhoea17 reports
- Leucocytosis NOS17 reports
- Lethargy (see also Central nervous system depression in 'Neurological')15 reports
- Anaemia NOS14 reports
- Anorexia14 reports
- Immune mediated thrombocytopenia14 reports
- Other abnormal test result NOS13 reports
- Lethargy (see also Central nervous system depression in Neurological)12 reports
- Neutrophilia11 reports
Cat
- Vomiting3 reports
- Agitation1 reports
- Anaemia NOS1 reports
- Anisocoria1 reports
- Ataxia1 reports
- Death1 reports
- Diarrhoea1 reports
- Digestive tract neoplasm NOS1 reports
- Dilated pupils1 reports
- Falling1 reports
- Open mouth breathing1 reports
- Recumbency1 reports
Monitoring1
CBC (less marrow-focused than vinblastine but still), neuro exam (proprioception, constipation), catheter site
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Hepatic disease (−50% if bili >2); leukopenia/infection; preexisting neuromuscular disease; MDR1 herding breeds — same P-gp caution as vinblastine
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The vincristine trio of tricks: CHOP lymphoma workhorse, TVT cure-in-a-vial, and a platelet bump for ITP (0.02 mg/kg once — pairs with prednisone; efficacy debated but traditional).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Constipation/ileus after vincristine in a cat = neurotoxicity, not "just GI upset" — anticipate (lactulose/stool softeners).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
mg/m² dosing (NOT mg/kg): a 30 kg dog gets ~0.6 m² → ~0.4 mg; a decimal error is a 10× overdose (cat lethal = 0.1 mg/kg).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Extravasation = tissue necrosis: free-flowing IV catheter, flush before and after.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
P-gp inhibitors — ↑ neurotoxicity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
L-asparaginase — Sequencing effects in lymphoma protocols (asparaginase first reduces vincristine clearance)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Other myelosuppressives — Additive marrow effect
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Tubulin binding → metaphase arrest (same as vinblastine); induces thrombocytosis (unknown mechanism) + mild immunosuppression
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Distribution — 75% tissue-bound; hepatic metabolism → biliary/fecal
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cross-resistance — NOT between vincas — resistance to one doesn't predict the other
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Potentially teratogenic — avoid.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1168–1170 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references13
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Docosahexaenoic acid improved vincristine-induced peripheral neuropathy in a rat model.
Study summary not available in the imported record. Open the original citation to review the study.
- Therapeutic Efficacy of 7‑Chloro-4-(phenylselanyl)quinoline against Oncological Pain Induced by Tumor Progression and Vincristine Treatment.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of Conventional and Ozonated Autohemotherapy as Adjuvant Treatment in Dogs with Transmissible Venereal Tumor (TVT).
Study summary not available in the imported record. Open the original citation to review the study.
- Antitumoral efficacy of silver nanoparticles reduced with β-D-glucose on a canine transmissible venereal tumor cell line.
Study summary not available in the imported record. Open the original citation to review the study.
- Vincristine-Induced Craniofacial Skeletal Teratogenicity in Foetal Rabbits: Multimodal Morphometric Assessment and Partial Protection by L-Carnitine.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.