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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Inflammatory large-bowel disease (colitis); adjunct for vasculitis
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Inflammatory large-bowel disease (colitis); adjunct for vasculitis — Extra-label (human drug)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Colitis — cautious use (salicylate sensitivity)
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Colitis — cautious use (salicylate sensitivity) — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects104
Keratoconjunctivitis sicca (KCS/dry eye) — Most frequent canine effect — may be irreversible; early detection allows reversal
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Anorexia, vomiting, cholestatic jaundice, hemolytic anemia, leukopenia, allergic dermatitis, ↓ sperm counts — Uncommon
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Sulfonamide hypersensitivity (Type I/III) — Large-breed dogs predisposed; Dobermans especially — many consider sulfonamides contraindicated in them
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Diarrhoea12 reports
- Lethargy (see also Central nervous system depression in 'Neurological')6 reports
- Behavioural disorder NOS4 reports
- Emesis4 reports
- Anorexia3 reports
- Emesis (multiple)3 reports
- Vomiting3 reports
- Anxiety2 reports
- Ataxia2 reports
- Death2 reports
- Death by euthanasia2 reports
- Decreased appetite2 reports
Monitoring1
Tear production (Schirmer): ~day 5 then q2–3 weeks; CBC (leukopenia/anemia); liver values; stool consistency
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Sulfonamide/salicylate hypersensitivity; intestinal or urinary obstruction; Doberman pinschers (idiosyncratic polysystemic immune-complex disease)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Preexisting liver/renal/hematologic disease; cats — salicylate sensitivity (see aspirin), keep courses ≤10 days
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Colonic bacteria are required to activate it — useless for small-intestinal inflammation. The pro-drug design delivers high local 5-ASA to the colon while sparing systemic salicylate exposure.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Schirmer tear testing on schedule is the monitoring hallmark — KCS can be irreversible if missed.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cats: once daily, short course, salicylate caution (same glucuronidation deficit as aspirin).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Overdose = combined salicylate + sulfonamide toxicity → urine alkalinization helps.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions5
Folic acid — Oral absorption inhibited
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Digoxin — Reduced absorption
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Ferrous sulfate/iron salts — ↓ sulfasalazine levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Warfarin — Potential potentiation
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Chlorpropamide — Hypoglycemia potentiation
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics2
Absorption — Only 10–33% absorbed orally; some biliary recycling
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
5-ASA — Mostly stays in colon (the therapeutic moiety); sulfapyridine absorbed → hepatic metabolism → renal excretion
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Human FDA category B; canine/feline class B (Papich 1989). 6× doses impaired male fertility (sulfapyridine, reversible). Sulfonamides in milk → kernicterus risk (human newborns) — caution nursing.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1094–1096; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 755–756 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references19
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- The endothelin-1/TLR4/NF-κB/NLRP3 inflammasome axis in preeclampsia: a review of a pathological feed-forward loop and therapeutic frontier.
Study summary not available in the imported record. Open the original citation to review the study.
- Sulfasalazine- and Cerium Ion-Loaded Polymersomes with Enhanced RONS Scavenging and Colonic Mucosal Repair Ameliorate Experimental Colitis.
Study summary not available in the imported record. Open the original citation to review the study.
- Development, Optimization, and Evaluation of Nano Self-Emulsifying Drug Delivery System Formulation Platform for Oral Bioavailability Enhancement of Sulfasalazine and Disulfiram in Lung Cancer Chemoprevention.
Study summary not available in the imported record. Open the original citation to review the study.
- Lung cancer chemo-interception by sulfasalazine and disulfiram codelivered using a nano self-emulsifying drug delivery system in mice.
Study summary not available in the imported record. Open the original citation to review the study.
- Impact of ERAP1 downregulation on the pathogenesis of DSS-induced colitis and therapeutic response to sulfasalazine.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.