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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Brucellosis (combination with aminoglycoside), Lyme disease, susceptible soft tissue/UTI, Nocardia/Actinomyces, nosocomial MDR infections, Ehrlichia
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Brucellosis (combination with aminoglycoside), Lyme disease, susceptible soft tissue/UTI, Nocardia/Actinomyces, nosocomial MDR infections, Ehrlichia — Extra-label (human drug)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Hemotropic mycoplasmosis (M. haemofelis), atypical mycobacterial dermal infections, mycoplasma/L-forms
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Hemotropic mycoplasmosis (M. haemofelis), atypical mycobacterial dermal infections, mycoplasma/L-forms — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens6
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects107
GI upset (vomiting, esophagitis) — Main effect — follow with water/food bolus
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Tooth discoloration — Young animals — less than other tetracyclines
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hepatotoxicity, vestibular signs (human hallmark) — Uncommon
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Lethargy (see also Central nervous system depression in 'Neurological')22 reports
- Other abnormal test result NOS19 reports
- Vomiting19 reports
- Anorexia17 reports
- Lack of efficacy (endoparasite) - heartworm14 reports
- Emesis13 reports
- INEFFECTIVE, HEARTWORM LARVAE13 reports
- Lack of efficacy - NOS13 reports
- Anaemia NOS10 reports
- Death by euthanasia10 reports
- Elevated alanine aminotransferase (ALT)9 reports
- Elevated serum alkaline phosphatase (SAP)9 reports
Cat
- Hyperexcitation1 reports
- Malaise1 reports
- Nausea1 reports
- Vomiting1 reports
Monitoring1
Clinical response; liver values if long courses; renal patients tolerated without dose change
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Pregnancy, young/growing animals, esophageal stricture patients (capsule retention)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Minocycline's rise = the doxycycline shortage/price workaround (Papich notes this explicitly) with near-equivalent spectrum, INCLUDING MRSP activity — a handy MDR skin-infection oral option when susceptibility confirms.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Same esophagitis-pill warning as doxycycline in cats: water chase/food bolus after dosing.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Renal-safe tetracycline (like doxycycline, unlike oxytetracycline) — usable in CKD patients with mycoplasma/HW-spit infections.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions4
Oral cations (Ca, Al, Fe, Mg — antacids, sucralfate) — Chelation → ↓ absorption (separate ≥2 h... minocycline less affected than doxy but still)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Warfarin — ↑ effect (class)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Penicillins — Antagonism (static vs cidal)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Digoxin — ↑ levels reported with tetracyclines
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Class action — 30S ribosome, bacteriostatic; mycoplasma/spirochetes/Rickettsia/Chlamydia + some staph/strep
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Renal safety — Can be used in renal insufficiency (unlike older tetracyclines)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Absorption — Higher fasting (dogs) — give 30 min pre-meal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Avoid in pregnancy/young animals (class tooth/bone effects — though minocycline less likely than others).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 845–846; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 535–536 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references15
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Quercetin as tigecycline adjuvant reverses multidrug-resistant Acinetobacter baumannii infection.
Study summary not available in the imported record. Open the original citation to review the study.
- Targeting the Redox-NF-κB/NLRP3 axis with intranasal liposomal minocycline mitigates aluminum-induced cognitive and structural deficits.
Study summary not available in the imported record. Open the original citation to review the study.
- Evaluation of autologous fecal microbiota transplantation for restoring equine gut microbiota after antibiotic-induced dysbiosis.
Study summary not available in the imported record. Open the original citation to review the study.
- Copper ions restore antibacterial activity of tigecycline by regulating photodegradation pathway under light exposure.
Study summary not available in the imported record. Open the original citation to review the study.
- T-2 Toxin Neurotoxicity: Molecular Mechanisms and Emerging Chemoprotective Strategies.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.