MDose · Veterinary drug reference
AMPICILLIN SULBACTAM
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Parenteral therapy of beta-lactamase-producing strains: E. coli, Pasteurella, Staph, Klebsiella, Proteus + susceptible Strep/Listeria; respiratory infections, serious bite wounds, intra-abdominal infections
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Parenteral therapy of beta-lactamase-producing strains: E. coli, Pasteurella, Staph, Klebsiella, Proteus + susceptible Strep/Listeria; respiratory infections, serious bite wounds, intra-abdominal infections — Extra-label (human drug) — the injectable counterpart of amoxicillin/clavulanate
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Parenteral therapy of beta-lactamase-producing strains: E. coli, Pasteurella, Staph, Klebsiella, Proteus + susceptible Strep/Listeria; respiratory infections, serious bite wounds, intra-abdominal infections — Extra-label (human drug) — the injectable counterpart of amoxicillin/clavulanate
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens6
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects202
Hypersensitivity (penicillin allergy) — Possible — the class risk
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
GI upset (oral flora disruption), injection pain — Occasional
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Elevated serum alkaline phosphatase (ALP)22 reports
- Death by euthanasia20 reports
- Lethargy (see also Central nervous system depression in Neurological)20 reports
- Elevated alanine aminotransferase (ALT)19 reports
- Diarrhoea18 reports
- Vomiting18 reports
- Abnormal radiograph finding17 reports
- Abnormal ultrasound finding17 reports
- Fever17 reports
- Elevated total bilirubin16 reports
- Hypoalbuminaemia16 reports
- Monocytosis16 reports
Cat
- Hyperglycaemia7 reports
- Intentional misuse7 reports
- Death by euthanasia6 reports
- Elevated creatinine6 reports
- Abdominal discomfort5 reports
- Anorexia5 reports
- Hyponatremia5 reports
- Hypoproteinaemia5 reports
- Hypothermia5 reports
- Not eating5 reports
- Abdominal effusion4 reports
- Abnormal radiograph finding4 reports
Monitoring1
Clinical response; renal function for dosing; injection sites
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Severe penicillin hypersensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Adjust interval in renal impairment; cross-reactivity with cephalosporins possible
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Mental model: "Unasyn = injectable Clavamox" — when a patient on amoxi/clav needs IV therapy (hospitalized pneumonia, bite wound cellulitis, septic abdomen), this is the form-factor switch, not a spectrum change.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
2:1 ratio expressed as combined mg — dose calculations use the total (ampicillin + sulbactam).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Anaerobic + Pasteurella coverage makes it a classic cat-bite abscess drug alongside source control/drainage.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Aminoglycosides — Synergy (gram-negatives) — separate IV lines (in vitro inactivation)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Tetracyclines/chloramphenicol (bacteriostatic) — Antagonism with the cidal penicillin
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Probenecid — ↑ penicillin levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Spectrum — Aminopenicillin coverage + beta-lactamase inhibition (sulbactam)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Route — Parenteral only (no oral form — that niche is amoxi/clav)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Renal, short half-life → frequent dosing
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Penicillin class — generally regarded as the safest antibiotic class in pregnancy.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 98–99 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references19
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Severe hypercalcemia in a cat following treatment with antibiotic impregnated calcium sulfate carrier material for chronic pyogranulomatous panniculitis.
Study summary not available in the imported record. Open the original citation to review the study.
- Biofilm production, molecular attributes and antibiotic resistance of Staphylococcus aureus isolated from bovine milk.
Study summary not available in the imported record. Open the original citation to review the study.
- The effect of papain on some bacterial pathogens in poultry meat.
Study summary not available in the imported record. Open the original citation to review the study.
- The effective role of organic acids as antibiotic alternatives in controlling necrotic enteritis in broiler chickens.
Study summary not available in the imported record. Open the original citation to review the study.
- Population pharmacokinetics of intravenous ampicillin in awake and anesthetised dogs.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
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