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Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Dose regimens1
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects21
Clinical signs in veterinary species associated with organophosphate and carbamate toxicity include frequent urination and defecation, muscle twitching, and watering eyes, followed by salivation, diarrhea, vomiting, and muscle weakness. This can proceed to anorexia, miosis or mydriasis, dyspnea, and bradycardia or tachycardia, and can also include more rapid involuntary muscle twitching and scattered fasciculations, followed by severe weakness and paralysis.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Abdominal discomfort1 reports
- Abdominal exudate1 reports
- Abnormal ultrasound finding1 reports
- Apathy1 reports
- Colitis1 reports
- Emesis (multiple)1 reports
- Fever1 reports
- Gastritis1 reports
- Hepatomegaly1 reports
- Lethargy (see also Central nervous system depression in Neurological)1 reports
- Loss of condition1 reports
- Mammary gland disorder NOS1 reports
Contraindications1
Sulfonamides are contraindicated in animals that are hypersensitive to them and in animals with severe renal or hepatic impairment.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Precautions1
For external use only on animals. Do not apply directly to areas such as waterers, feed troughs, or mangers. Do not contaminate water, feed, troughs, feed handling equipment, or milk or meat handling equipment. Use with caution in very young, weak, or debilitated animals. Overuse may increase the risk of adverse events. In the case of overdose, treat with atropine sulfate or 2-PAM as soon as possible.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Literature references19
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- History repeats in sweet solutions: toxicological concerns and targeted recommendations following the cough syrup-linked paediatric mortalities in India.
Study summary not available in the imported record. Open the original citation to review the study.
- Transformation process and phytotoxicity of sulfamethoxazole and N4-acetyl-sulfamethoxazole in rice.
Study summary not available in the imported record. Open the original citation to review the study.
- Assessment of the combined inputs of antimicrobials from top soil improvers and irrigation waters on green leafy vegetable fields.
Study summary not available in the imported record. Open the original citation to review the study.
- Biosorption and biotransformation behaviours of veterinary antibiotics under aerobic livestock wastewater treatment processes.
Study summary not available in the imported record. Open the original citation to review the study.
- Nature of Luminescence and Pharmacological Activity of Sulfaguanidine.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: DailyMed, U.S. National Library of Medicine; PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.