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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Exocrine pancreatic insufficiency (EPI) — enzyme replacement; diagnostic-therapeutic trial for insufficiency secondary to chronic pancreatitis
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Exocrine pancreatic insufficiency (EPI) — enzyme replacement; diagnostic-therapeutic trial for insufficiency secondary to chronic pancreatitis — Extra-label (human/veterinary supplements)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Exocrine pancreatic insufficiency (EPI) — enzyme replacement; diagnostic-therapeutic trial for insufficiency secondary to chronic pancreatitis — Extra-label (human/veterinary supplements)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects108
Oral bleeding — Dose-related — resolves with dose reduction; moistening the food/enzyme mix decreases it
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
GI distress at high doses — Possible
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting7 reports
- Diarrhoea6 reports
- Lethargy (see also Central nervous system depression in 'Neurological')4 reports
- Other abnormal test result NOS4 reports
- Anorexia3 reports
- Abnormal stool colouration2 reports
- Abnormal ultrasound finding2 reports
- Anaemia NOS2 reports
- Bloody diarrhoea2 reports
- Death2 reports
- Death by euthanasia2 reports
- Elevated alanine aminotransferase (ALT)2 reports
Cat
- Death by euthanasia1 reports
- Intestinal disorder NOS1 reports
- Pain NOS1 reports
- Rectal prolapse1 reports
- Retching1 reports
- Vocalisation1 reports
Monitoring1
Body weight (target optimal/maintain), stool consistency/frequency; TLI established the diagnosis (canine)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Pork-protein hypersensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Guard owners on powder handling (inhalation/asthma)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
EPI non-responders think three causes: ineffective enzyme product, too-fatty diet, or concurrent antibiotic-responsive enteropathy — before calling it refractory.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
~15% of dogs with EPI never respond to therapy (guarded prognosis).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Enzymes + small frequent meals + possible B12 (cobalamin) supplementation is the full EPI package — cobalamin deficiency is a common co-morbid cause of poor response.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Treatment is lifelong; doses are titrated to the lowest effective (varies between patients AND batches of supplement).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions2
Antacids/H2/PPI may be co-used — Sometimes needed (acid deactivates enzymes); not an interaction per se
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
No significant systemic interactions — Local action
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics2
Action — Local intraluminal digestion (fat/protein/carb) — no systemic absorption relevant
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Potency — ≥4× trypsin/amylase and ≥12× lipase vs plain pancreatin per mg
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
No specific concerns identified in sources.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 932–933; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 604–605 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references7
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Pharmacokinetics of Sodium Selenite Administered Orally in Blood and Tissues of Selenium-Deficient Ducklings.
Study summary not available in the imported record. Open the original citation to review the study.
- Randomized placebo controlled clinical trial of an enteric coated micro-pelleted formulation of a pancreatic enzyme supplement in dogs with exocrine pancreatic insufficiency.
Study summary not available in the imported record. Open the original citation to review the study.
- Metabolic markers of protein maldigestion after a (15)N test meal in minipigs with pancreatic exocrine insufficiency.
Study summary not available in the imported record. Open the original citation to review the study.
- Comparison of various solutions to dissolve critical care diet clots.
Study summary not available in the imported record. Open the original citation to review the study.
- The growing pancreatic duct ligated pig as a model for exocrine pancreatic insufficiency in children: investigations to achieve sufficient vitamin A and vitamin E supply.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.