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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications4
Flea population control (≥6 weeks; Sentinel combo ≥4 weeks for +HW/intestinal parasites) — does NOT kill adults or pupae
DogCatOn-label (ON_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Flea population control (≥6 weeks; Sentinel combo ≥4 weeks for +HW/intestinal parasites) — does NOT kill adults or pupae — Authorized (label)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Flea population control (≥6 weeks; Sentinel combo ≥4 weeks for +HW/intestinal parasites) — does NOT kill adults or pupae — Authorized (label)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Adjunct for dermatophytosis (fungi use chitin too)
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Adjunct for dermatophytosis (fungi use chitin too) — Extra-label adjunct
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Adjunct for dermatophytosis (fungi use chitin too) — Extra-label adjunct
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects201
None at recommended doses — The cleanest safety line in the library
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- INEFFECTIVE, HEARTWORM LARVAE5,704 reports
- Vomiting5,401 reports
- Lack of efficacy (endoparasite) - hookworm4,233 reports
- Lack of efficacy (endoparasite) - heartworm3,521 reports
- Diarrhoea3,070 reports
- INEFFECTIVE, ASCARIDS NOS1,998 reports
- Lethargy (see also Central nervous system depression in 'Neurological')1,878 reports
- INEFFECTIVE, HOOKS1,868 reports
- Lack of efficacy - NOS1,359 reports
- Lack of efficacy (endoparasite) - whipworm1,328 reports
- Lack of efficacy (ectoparasite) - flea1,218 reports
- Depression1,126 reports
Cat
- Vomiting220 reports
- Depression214 reports
- Anorexia199 reports
- Injection site mass110 reports
- Injection site swelling86 reports
- Fever79 reports
- Injection site abscess71 reports
- Diarrhoea66 reports
- Lack of efficacy (ectoparasite) - flea64 reports
- Death63 reports
- Weight loss54 reports
- Injection site lump53 reports
Monitoring1
Clinical: Flea population trend over 2–3 months (the lag); fungal cultures q2–4 wk when used for ringworm
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
All pets in household must be treated (untreated animals = reservoir); no tick activity; not monotherapy for established infestations
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
"Flea birth control": the exam-ready one-liner — adults live, eggs die; pair an adulticide (Capstar/spinosad/spot-on) because clients want visible fleas gone NOW, lufenuron handles the future.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The 60–90 day lag and all-pets-treated rules are the two counseling points that prevent "it doesn't work" complaints.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Chitin-in-fungi recycling: the same mechanism justifies dermatophytosis adjunct use (weaker evidence, never solo).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions2
Nitenpyram — The deliberate classic pair (knockdown adulticide + IGR)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Spot-ons/oral adulticides — Recommended combination for real-world control (Ihrke)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Chitin synthesis inhibition — flea eggs fail to hatch; larval maturation fails; no adult kill, no repellency
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Lag — 60–90 days to visible population effect — the expectations-setting number
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Safety — Essentially adverse-effect-free at doses; environmentally benign
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Considered safe (label permits use in breeding animals).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 743–744 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references16
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Nationwide Monitoring and Risk Assessment of Pesticide Residues in Fishery Products.
Study summary not available in the imported record. Open the original citation to review the study.
- EVALUATING BAITS WITH LUFENURON AND NITENPYRAM FOR FLEA CONTROL ON PRAIRIE DOGS (CYNOMYS SPP.) TO MITIGATE PLAGUE.
Study summary not available in the imported record. Open the original citation to review the study.
- Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio(®) Plus) for the prevention of heartworm disease (Dirofilaria immitis) in client-owned dogs in the USA.
Study summary not available in the imported record. Open the original citation to review the study.
- Posttreatment temperature influences toxicity of insect growth regulators in Musca domestica.
Study summary not available in the imported record. Open the original citation to review the study.
- Humoral immune responses and gill antioxidant-related gene expression of common carp (Cyprinus carpio) exposed to lufenuron and flonicamide.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.