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Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Chronic low-grade intestinal lymphoma (with prednisolone); refractory/severe IBD; pemphigus foliaceus; eosinophilic granuloma complex — preferred over cyclophosphamide/azathioprine for cat safety
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Chronic low-grade intestinal lymphoma (with prednisolone); refractory/severe IBD; pemphigus foliaceus; eosinophilic granuloma complex — preferred over cyclophosphamide/azathioprine for cat safety — Extra-label (human drug)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Lymphocytic leukemia, multiple myeloma, polycythemia vera, macroglobulinemia; immunosuppression (glomerulonephritis 0.1–0.2 mg/kg q24–48h; alternative in IMHA/immune disease)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Lymphocytic leukemia, multiple myeloma, polycythemia vera, macroglobulinemia; immunosuppression (glomerulonephritis 0.1–0.2 mg/kg q24–48h; alternative in IMHA/immune disease) — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects203
Myelosuppression (mild, gradual) — Lower than cyclophosphamide — the point of choosing it
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
GI toxicity, anorexia — Occasional
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Rare neurologic signs (myoclonus reported — human) — Uncommon
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting5 reports
- Death4 reports
- Other abnormal test result NOS4 reports
- Death by euthanasia3 reports
- Diarrhoea3 reports
- Inappropriate urination3 reports
- Neutropenia3 reports
- Abnormal ultrasound finding2 reports
- Anorexia2 reports
- Decreased appetite2 reports
- Emesis2 reports
- Localised hair loss2 reports
Cat
- Death by euthanasia14 reports
- Lack of efficacy - NOS11 reports
- Weight loss10 reports
- Vomiting9 reports
- Anorexia8 reports
- Diarrhoea8 reports
- Lethargy (see also Central nervous system depression in 'Neurological')7 reports
- Other abnormal test result NOS7 reports
- Behavioural disorder NOS5 reports
- Ataxia4 reports
- Death4 reports
- Decreased appetite4 reports
Monitoring1
CBC q2–4 wk (gentler schedule than pulse chemo); GI signs; response markers (albumin/weight in enteropathy; globulins in myeloma)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Preexisting marrow depression; active infection; prior resistance to alkylators
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Chlorambucil is the cat's alkylator: slow, oral, low-marrow-toxicity — the backbone of small-cell intestinal lymphoma therapy (with pred) and steroid-refractory IBD.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cyclophosphamide → hemorrhagic cystitis and harsher marrow hits; chlorambucil → none of the bladder risk — the swap rationale in chronic feline therapy.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The 2 mg tablet is a convenient cat-sized dose — the q48h-vs-q72h (>4 kg vs <4 kg) split is the practical dosing pearl.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Polycythemia vera and multiple myeloma: the quieter chronic indications alongside the GI ones.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions2
Other myelosuppressives — Additive
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Prednisolone — The standard deliberate combination (feline lymphoma/IBD)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — DNA cross-linking alkylator (nitrogen mustard), cell-cycle non-specific — slowest/mildest of the class
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Absorption — Rapid, nearly complete oral; peak ~1 h
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Hepatic → phenylacetic acid mustard (active) → urinary metabolites
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Potential teratogen — avoid.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 248–249 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references17
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Suspected chronic eosinophilic leukemia in a cat treated with toceranib.
Study summary not available in the imported record. Open the original citation to review the study.
- Retrospective evaluation of short- and medium-term therapeutic response to different immunosuppressive and dietary approaches in 148 dogs diagnosed with immunosuppressant-responsive enteropathy.
Study summary not available in the imported record. Open the original citation to review the study.
- Chlorambucil Monotherapy in Dogs with Protein-Losing Nephropathy of Probable Immune Origin: A Preliminary Study.
Study summary not available in the imported record. Open the original citation to review the study.
- Use of Immunosuppression, Romiplostim, and Splenectomy to Achieve Remission in a British Shorthair Cat With Primary Immune-Mediated Thrombocytopenia.
Study summary not available in the imported record. Open the original citation to review the study.
- Retrospective Safety Evaluation of Combined Chlorambucil and Toceranib for the Treatment of Different Solid Tumours in Dogs.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.