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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Chronic enteropathy / antibiotic-responsive diarrhea (ARD); tylosin-responsive diarrhea; tear staining (epiphora, extra-label cosmetic)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Chronic enteropathy / antibiotic-responsive diarrhea (ARD); tylosin-responsive diarrhea; tear staining (epiphora, extra-label cosmetic) — Extra-label (injectable dog/cat-approved; oral use extra-label)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
IBD adjunct; Clostridium perfringens colitis; anecdotal immunomodulator in FIP
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: IBD adjunct; Clostridium perfringens colitis; anecdotal immunomodulator in FIP — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects205
GI upset (anorexia, diarrhea) — Main oral effect
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pain/local reaction at IM injection sites — Injectable use (rare parenteral use in small animals)
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Fatal colitis — Horses — contraindicated (species note)
HorseNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Diarrhoea85 reports
- Vomiting79 reports
- Lack of efficacy - NOS57 reports
- Lethargy (see also Central nervous system depression in 'Neurological')47 reports
- Anorexia40 reports
- Other abnormal test result NOS39 reports
- Emesis37 reports
- Death by euthanasia28 reports
- Not eating28 reports
- UNPALATABLE27 reports
- Death26 reports
- Behavioural disorder NOS24 reports
Cat
- Diarrhoea12 reports
- Hypersalivation10 reports
- Vomiting10 reports
- Lack of efficacy (bacteria) - NOS7 reports
- UNPALATABLE7 reports
- Behavioural disorder NOS4 reports
- Lameness3 reports
- Loose stool3 reports
- Not eating3 reports
- Alopecia NOS2 reports
- Anaemia NOS2 reports
- Application site alopecia2 reports
Monitoring1
Stool consistency over the trial period; appetite; ALT/AST note: macrolides falsely elevate transaminases on colorimetric assays
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Macrolide hypersensitivity; horses (severe/fatal diarrhea)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Oral ruminant use causes severe diarrhea (species note)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Tylosin-responsive diarrhea is a real, relapsing phenotype: stool normalizes while on treatment and diarrhea returns within weeks of stopping (Kilpenn) — owners of responders often need long-term pulse or continuous low-dose therapy.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Bacteriostatic 50S binder like erythromycin — but at canine/feline doses its clinical niche is chronic enteropathy, not systemic infection.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
May also act immunomodulatorily and increase jejunal probiotic enterococci — rationale beyond pure antibiosis.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Safety margin is wide (2-year 400 mg/kg/day oral studies in dogs without organ toxicity).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions2
Digoxin — Possible ↑ digoxin levels (macrolide class effect) — monitor
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Erythromycin-class interactions — Cross-resistance; see erythromycin interactions
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics4
Absorption — Tartrate well absorbed orally; phosphate less so
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — ~54 min (small animals)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Distribution — Vd 1.7 L/kg; poor CSF penetration
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Urine + bile, unchanged
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Canine/feline pregnancy class B (Papich 1989) — safe if used cautiously.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1153–1154; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 826–827 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references14
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Antibiotic exposure during weaning disrupts oral microbiota assembly in piglets.
Study summary not available in the imported record. Open the original citation to review the study.
- Effect of Methyl Gallate on Physiological and Gut Microbiota-Associated Responses Following a Single Intramuscular Administration of Tylosin in Weaned Piglets.
Study summary not available in the imported record. Open the original citation to review the study.
- A Decision-Oriented Calibrated Screening Workflow for Tylosin Derivatives: Closed-Loop MIC Validation Against Staphylococcus aureus and Streptococcus agalactiae.
Study summary not available in the imported record. Open the original citation to review the study.
- Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases.
Study summary not available in the imported record. Open the original citation to review the study.
- Bibliometric analysis of pharmacokinetic research on the combination of norfloxacin and tylosin in poultry and reptiles.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.