MDose · Veterinary drug reference
KETOCONAZOLE
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Histoplasmosis (still considered drug of choice by some), other systemic mycoses, hyperadrenocorticism (short-term/palliative), cyclosporine dose-sparing
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Histoplasmosis (still considered drug of choice by some), other systemic mycoses, hyperadrenocorticism (short-term/palliative), cyclosporine dose-sparing — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Systemic mycoses — controversial, some clinicians avoid entirely
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Systemic mycoses — controversial, some clinicians avoid entirely — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects206
GI (anorexia, vomiting, diarrhea) — Most common, more prevalent
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hepatotoxicity (cholangiohepatitis, ↑enzymes) — Idiosyncratic or dose-related
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Thrombocytopenia — Rare
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Reversible lightening of haircoat — Reported
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
↓ Testosterone/cortisol synthesis — Dose-related, transient
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Lack of efficacy - NOS349 reports
- Vomiting295 reports
- Other abnormal test result NOS204 reports
- Lethargy (see also Central nervous system depression in 'Neurological')197 reports
- Diarrhoea192 reports
- Emesis150 reports
- Anorexia108 reports
- Ataxia108 reports
- Loss of hearing108 reports
- Weight loss100 reports
- Behavioural disorder NOS91 reports
- Deafness89 reports
Cat
- Ataxia31 reports
- Horner's syndrome16 reports
- Weight loss16 reports
- Third eyelid protrusion14 reports
- Head tilt - ear disorder13 reports
- Anisocoria12 reports
- Not eating12 reports
- Anorexia11 reports
- Decreased appetite10 reports
- Lack of efficacy - NOS10 reports
- Ear infection NOS9 reports
- Head shake - ear disorder9 reports
Monitoring1
Baseline + periodic liver enzymes; cortisol levels if used for HAC
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Hypersensitivity; many consider cats a relative/absolute contraindication
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Hepatic disease, thrombocytopenia; male breeding dogs (testosterone suppression, reversible)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Most potent CYP450/P-glycoprotein inhibitor of the azole antifungals — highest drug interaction burden of the group; never combine with ivermectin.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Considered inferior to mitotane for long-term HAC control but useful for short-term stabilization or palliative therapy before surgery.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Give with food to improve tolerance in animals prone to GI upset; absorption is acid-dependent so avoid concurrent acid-reducing drugs.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions5
Ivermectin — ↑ neurotoxicity risk — at least one source states never combine in dogs
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cyclosporine — ↑ levels significantly — deliberately exploited for dose-sparing
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Mitotane — Do not combine for HAC treatment — ketoconazole inhibits mitotane's adrenolytic effect
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
H2-blockers/antacids/PPIs — ↓ absorption — avoid concurrent
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Digoxin, quinidine, warfarin, cisapride — ↑ levels of these drugs via CYP inhibition
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Bioavailability — Highly variable, 4–89% (dog)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — 84–99%
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — 1–6h, avg 2.7h (dog)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Extensive hepatic, inactive metabolites
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Primarily fecal/biliary
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Known teratogen/embryotoxin in rats; mummified fetuses/stillbirths reported in treated dogs. Papich canine/feline class B, but use with caution given teratogenicity data. Excreted in milk.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 697–699; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 430–431 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references12
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Evaluation of antimicrobial efficacy of Psidium guajava L. leaf extract in ketoconazole shampoo.
Study summary not available in the imported record. Open the original citation to review the study.
- Design and Synthesis of Ketoconazole Derivatives as Innovative Anti-Infective Agents.
Study summary not available in the imported record. Open the original citation to review the study.
- Plasma Protein Binding, Biostability, Metabolite Profiling, and CYP450 Phenotype of TPB15 Across Different Species: A Novel Smoothened Inhibitor for TNBC Therapy.
Study summary not available in the imported record. Open the original citation to review the study.
- Comparative efficacy of selenoureido carbonic anhydrase inhibitors and azole antifungal drugs against clinical isolates of Malassezia pachydermatis.
Study summary not available in the imported record. Open the original citation to review the study.
- Phototoxic reaction to oral terbinafine due to Tinea capitis in a child.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
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