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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Canine cognitive dysfunction ("old dog dementia"); pituitary-dependent hyperadrenocorticism (Cushing's — efficacy controversial)
DogOn-label (ON_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Canine cognitive dysfunction ("old dog dementia"); pituitary-dependent hyperadrenocorticism (Cushing's — efficacy controversial) — FDA-approved (Anipryl)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Feline cognitive dysfunction syndrome
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Feline cognitive dysfunction syndrome — Extra-label, anecdotal support only
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens6
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
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Adverse effects146
Vomiting, diarrhea — Reported
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
CNS effects: restlessness, repetitive movements, hyperactivity, lethargy — Reported, more likely at high doses (>0.3 mg/kg above label in some data)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Diminished hearing/deafness, pruritus, licking, tremors — Reported
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting449 reports
- INEFFECTIVE, COGNITIVE DYSFUNC439 reports
- INEFFECTIVE, LOSS OF EFFECT338 reports
- Diarrhoea337 reports
- Anorexia324 reports
- Lack of efficacy - NOS311 reports
- Depression301 reports
- Restlessness262 reports
- INEFFECTIVE, CUSHINGS252 reports
- Death by euthanasia243 reports
- Convulsion231 reports
- Elevated serum alkaline phosphatase (SAP)226 reports
Cat
- Accidental exposure15 reports
- No sign8 reports
- Vomiting7 reports
- Depression4 reports
- Anorexia3 reports
- Death3 reports
- Lack of efficacy - NOS3 reports
- Ataxia2 reports
- Behavioural disorder NOS2 reports
- Convulsion2 reports
- Diarrhoea2 reports
- INEFFECTIVE, COGNITIVE DYSFUNC2 reports
Monitoring1
Clinical response (physical exam, history — primary methods). Low-dose dexamethasone suppression test does not correlate with clinical efficacy for Cushing's — don't rely on it to judge response.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications3
Known hypersensitivity; not indicated for adrenal tumors (non-PDH Cushing's)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
SSRIs, TCAs, SNRIs
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Table 1 (p.630), row: Selegiline, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
- Cat · Table 1 (p.630), row: Selegiline, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
Precautions4
Confirm PDH diagnosis before treating for Cushing's — do not use for adrenal-dependent disease; potential for human abuse (amphetamine metabolites) — be alert for drug "shoppers"
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Efficacy for PDH Cushing's is considered inferior to trilostane or mitotane — set expectations accordingly; may only help lesions involving the pars intermedia.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
For cognitive dysfunction, benefit may take weeks to become apparent — don't judge failure too early.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
RCI Class 2 controlled substance for competition animals — relevant in performance/sporting dog contexts.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions4
Opioids (esp. meperidine) — Manufacturer recommends against concurrent use — severe reaction risk (extrapolated from human data); 2-week separation advised
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
SSRIs (fluoxetine), TCAs (clomipramine, amitriptyline), tramadol — Serotonin syndrome risk — avoid/separate by ≥2 weeks
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Amitraz — Manufacturer specifically advises against concurrent use
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Ephedrine, phenylpropanolamine, pseudoephedrine — Risk of hypertension/hyperpyrexia
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Bioavailability — ~10% (absolute, dog)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — ~1 hour (terminal, dog)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Extensive hepatic → L-amphetamine, L-methamphetamine (active) metabolites
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Safety not established in pregnant/breeding/lactating animals. No overt teratogenicity in rat studies. Human FDA category C. Unknown if excreted in milk.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1055–1056; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 722–723 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references17
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Current practices for diagnosis and management of Canine Cognitive Dysfunction Syndrome in the United States.
Study summary not available in the imported record. Open the original citation to review the study.
- The MAO-B Inhibitor Selegiline Reduces the Viability of Different Prostate Cancer Cell Lines and Enhances the Effects of Anti-Androgen and Cytostatic Agents.
Study summary not available in the imported record. Open the original citation to review the study.
- Protective Effect of Selegiline (R-deprenyl) in Aminoglycoside-Induced Hearing Loss.
Study summary not available in the imported record. Open the original citation to review the study.
- Assessment of selegiline and trilostane combined therapy efficacy for canine pituitary-dependent hypercortisolism treatment: A pilot randomized clinical trial.
Study summary not available in the imported record. Open the original citation to review the study.
- Betahistine Treatment in a Cat Model of Vestibular Pathology: Pharmacokinetic and Pharmacodynamic Approaches.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Perrin C, Seksel K, Landsberg GM. Appendix: Drug Dosage Chart. Vet Clin Small Anim 2014;44:629-632.; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.