MDose · Veterinary drug reference
AZITHROMYCIN
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Bordetella pneumonia, pyoderma, Babesia gibsoni adjunct
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Bordetella pneumonia, pyoderma, Babesia gibsoni adjunct — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Upper respiratory infection, Bartonellosis
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Upper respiratory infection, Bartonellosis — Extra-label — ineffective for Mycoplasma haemofelis or clearing Chlamydophila felis
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects204
Vomiting — Dose-related, less than erythromycin
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Diarrhea — Occasional
CatHorseNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Local IV site reaction — With IV use
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting13 reports
- Lethargy (see also Central nervous system depression in 'Neurological')10 reports
- Papilloma8 reports
- Elevated alanine aminotransferase (ALT)7 reports
- Not eating7 reports
- Other abnormal test result NOS7 reports
- Death by euthanasia6 reports
- Diarrhoea6 reports
- Emesis6 reports
- Lack of efficacy (endoparasite) - heartworm6 reports
- Death5 reports
- Elevated serum alkaline phosphatase (SAP)5 reports
Cat
- Lethargy (see also Central nervous system depression in 'Neurological')14 reports
- Vomiting12 reports
- Not eating11 reports
- Death10 reports
- Death by euthanasia10 reports
- Decreased appetite9 reports
- Weight loss9 reports
- Lack of efficacy - NOS8 reports
- Nasal discharge8 reports
- Anorexia7 reports
- Fever7 reports
- Behavioural disorder NOS6 reports
Monitoring1
Clinical efficacy, GI tolerance
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Macrolide hypersensitivity; do not give IV as bolus or IM
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions3
Hepatic impairment; history of vomiting
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Long tissue half-life allows intermittent (every-other-day to twice-weekly) dosing after an initial loading course — useful for owners who struggle with daily pilling.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Despite common use for feline URI, do not rely on it for confirmed Mycoplasma haemofelis or to eliminate Chlamydophila felis — it isn't effective for those specific organisms even though clinical signs may improve (likely via immunomodulatory effects).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions4
Antacids (Mg/Al-containing) — ↓ absorption — separate by 2h
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cyclosporine — May ↑ cyclosporine levels — monitor
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Digoxin — Other macrolides raise digoxin levels — monitor
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pimozide — Contraindicated combination (arrhythmia risk, human)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics4
Bioavailability — 97% (dog, Plumb's)/90% (Papich); 58% (cat)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — Plasma: 30h (dog), 35h (cat); tissue half-lives up to 90h (dog)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Minimal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — >50% biliary/fecal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Not fully established. Human FDA category B.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 136–139; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 66–69 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references19
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Determining intracellular and extracellular activities of azithromycin against azithromycin-resistant Salmonella Typhi and their association with clinical treatment responses.
Study summary not available in the imported record. Open the original citation to review the study.
- Global trends and molecular epidemiology of Azithromycin-resistant Salmonella: A systematic review and meta-analysis.
Study summary not available in the imported record. Open the original citation to review the study.
- Genomic analysis of Campylobacter risk in retail chicken isolated from Beijing in 2024.
Study summary not available in the imported record. Open the original citation to review the study.
- Prevalence, antimicrobial resistance, and risk factors of Salmonella in Cattle, environment, and workers at gombe township abattoir, Nigeria, with an assessment of workers' knowledge, attitudes, and practices.
Study summary not available in the imported record. Open the original citation to review the study.
- Risk ranking and antimicrobial resistance of Shiga toxin-producing Escherichia coli of bovine origin.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.