MDose · Veterinary drug reference
ASPIRIN
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Analgesia/antipyresis/anti-inflammatory (buffered products); antiplatelet adjunct (IMHA, glomerular disease, heartworm post-adulticide thromboprophylaxis)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Analgesia/antipyresis/anti-inflammatory (buffered products); antiplatelet adjunct (IMHA, glomerular disease, heartworm post-adulticide thromboprophylaxis) — Extra-label (never FDA-approved for animals)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Analgesia/antipyretic (cautious dosing); ATE prophylaxis in cardiomyopathy
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Analgesia/antipyretic (cautious dosing); ATE prophylaxis in cardiomyopathy — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens8
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects179
GI ulceration/bleeding — Dogs relatively sensitive even at antiplatelet doses
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Toxicity (tinnitus-analog, CNS, acid-base, hyperthermia) — Overdose/accumulation
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hepatotoxicity — High-dose chronic
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting46 reports
- Death by euthanasia40 reports
- Anorexia32 reports
- Diarrhoea31 reports
- Lethargy (see also Central nervous system depression in 'Neurological')28 reports
- Other abnormal test result NOS24 reports
- Emesis20 reports
- Weight loss19 reports
- Death17 reports
- Decreased appetite16 reports
- Seizure NOS15 reports
- Abnormal radiograph finding14 reports
Cat
- Anaemia NOS6 reports
- Death by euthanasia6 reports
- Lack of efficacy - NOS4 reports
- Leucocytosis NOS4 reports
- Vomiting4 reports
- Azotaemia3 reports
- Fever3 reports
- Not eating3 reports
- Abdominal effusion2 reports
- Anorexia2 reports
- Decreased appetite2 reports
- Head tremor2 reports
Monitoring1
GI signs (melena, vomiting), renal values on chronic therapy; no routine platelet monitoring available
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications2
Hypersensitivity; active GI bleed/bleeding ulcers
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Bleeding disorders, asthma, renal insufficiency (though low-dose used in glomerular disease)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions6
Hypoalbuminemia (↓ dose); stop ~1 week pre-surgery; caution with severe hepatic/renal disease; do NOT combine with other NSAIDs
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cat dosing interval is every 2–3 DAYS, not daily — the 27–45 h feline half-life (glucuronidation deficiency) makes daily dosing a classic overdose trap.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Aspirin's COX-1 inhibition in platelets is irreversible (platelets cannot resynthesize COX) → antiplatelet effect lasts the platelet lifespan (~7 days).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Aspirin resistance documented: low doses may fail to inhibit aggregation in some animals (COX-2-derived thromboxane) — clopidogrel adds independent, superior inhibition in cats.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Heartworm thromboprophylaxis benefit is unproven; some evidence suggests aspirin may be contraindicated in heartworm disease (Papich).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions5
Other NSAIDs / corticosteroids — ↑ GI ulceration risk — avoid stacking
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Anticoagulants (heparin, warfarin), clopidogrel — ↑ bleeding
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Highly protein-bound drugs — Displacement interactions
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Urinary acidifiers — ↓ salicylate excretion → accumulation
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Carbonic anhydrase inhibitors, methotrexate — ↑ levels/toxicity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Absorption — Rapid (stomach + proximal SI)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — 90% at low levels → 70% at high
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — Dog ~8 h; Cat 27–45 h (Papich: 8.5 h dog, 38 h cat)
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Hepatic glycine/glucuronide conjugation
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Renal, pH-dependent (alkalinizing urine ↑ excretion)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Low-grade teratogen; delays parturition — avoid in pregnancy. Crosses placenta (fetal levels can exceed maternal). Low levels in milk.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 114–117; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 53–54 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references20
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Multi-level biomarker responses in the marine mussel Mytilus galloprovincialis exposed to a mixture of Dexamethasone and Acetylsalicylic Acid.
Study summary not available in the imported record. Open the original citation to review the study.
- Evaluating the Effect of Acetylsalicylic Acid in Turkey Poults Experimentally Infected with Coccidia.
Study summary not available in the imported record. Open the original citation to review the study.
- Semaglutide and Cardiovascular Outcomes According to Baseline Aspirin Use: Analyses of the SOUL and SELECT Trials.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of gut barrier dysfunction during a viral respiratory disease challenge on immune function of feedlot beef calves.
Study summary not available in the imported record. Open the original citation to review the study.
- Acanthamoeba castellanii: Non-Steroidal Anti-Inflammatory Drugs Affect Adhesion, Motility, and Encystment, Suggesting a Link with a gp63-like Protein Candidate.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
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