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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Lymphoma (combination protocols), mast cell tumors (more effective than vincristine), carcinomas, splenic tumors, transmissible venereal tumor
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Lymphoma (combination protocols), mast cell tumors (more effective than vincristine), carcinomas, splenic tumors, transmissible venereal tumor — Extra-label (human drug)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Lymphoma and other neoplasms in combination protocols
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Lymphoma and other neoplasms in combination protocols — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens3
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects81
Myelosuppression (worse than vincristine) — neutropenia nadir ~day 4–7 — Dose-limiting
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Gastroenterocolitis (nausea/vomiting/diarrhea), stomatitis, constipation, alopecia — Common
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Neurotoxicity: constipation, paralytic ileus, anorexia aggravation, axonal swelling/demyelination (reversible) — Cats especially
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Jaw/muscle pain, loss of deep tendon reflexes — Chronic use
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Diarrhoea5 reports
- Elevated serum alkaline phosphatase (SAP)5 reports
- Decreased appetite4 reports
- Elevated alanine aminotransferase (ALT)4 reports
- Vomiting4 reports
- Anaemia NOS3 reports
- Anorexia3 reports
- Death by euthanasia3 reports
- Elevated liver enzymes3 reports
- Lethargy (see also Central nervous system depression in 'Neurological')3 reports
- Neutropenia3 reports
- Other abnormal test result NOS3 reports
Cat
- Lethargy (see also Central nervous system depression in 'Neurological')2 reports
- Behavioural disorder NOS1 reports
- Death by euthanasia1 reports
- Emesis1 reports
- Leucocytosis NOS1 reports
- Lymphocytosis1 reports
- Not eating1 reports
- Sedation1 reports
Monitoring1
CBC with differential (nadir check ~day 7) before each dose; liver values; neuro/GI signs; catheter patency at injection
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Preexisting leukopenia/granulocytopenia (unless disease-related), active bacterial infection
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Hepatic dysfunction (reduce 50%); herding breeds/MDR1 (reduce 25–30%, monitor); preexisting neuromuscular disease
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Same family, opposite toxicities: vinblastine = marrow-toxic, vincristine = neuro-toxic — the classic exam contrast. Vinblastine is the MCT drug; vincristine the lymphoma/ITP drug.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
MDR1/ABCB1 herding breeds: both vincas are P-gp substrates — 25–30% dose reduction (WSU lab guidance) in mutant/mutant AND mutant/normal dogs.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Lethal dose reported at 0.2 mg/kg in dogs — a small overdose of a tiny-volume drug; double-check the math (mg/m², not mg/kg!).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Vesicant discipline: dedicated clean line, flush before/after, no subcutaneous leakage (tissue necrosis).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
P-gp inhibitors (cyclosporine, ketoconazole etc.) — ↑ neurotoxicity risk (P-gp substrate like vincristine/loperamide)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Methotrexate — Sequencing interactions (human oncology)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Phenobarbital — Altered metabolism possible
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Tubulin/microtubule binding → metaphase arrest; also inhibits amino-acid/purine metabolism
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Distribution — 75% tissue-bound; no CNS entry
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Extensive hepatic metabolism → biliary/fecal
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Potentially teratogenic — avoid.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1165–1167 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references14
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Adverse events in small dogs treated with a single dose of vinblastine.
Study summary not available in the imported record. Open the original citation to review the study.
- Synergistic effects of H(2)O(2), melatonin, and L-cysteine on biochemical traits and alkaloid accumulation in Catharanthus roseus L. "Ocellatus" in vitro plants.
Study summary not available in the imported record. Open the original citation to review the study.
- The effect of spraying tryptophan on the physiological characteristics of the periwinkle plant (Catharanthus roseus L.) under drought stress.
Study summary not available in the imported record. Open the original citation to review the study.
- Combination chemotherapy of imatinib, vinblastine, and prednisolone in a dog with cutaneous mast cell tumor: Evaluation of treatment response with (18)F-fluorodeoxyglucose positron emission tomography.
Study summary not available in the imported record. Open the original citation to review the study.
- Use of Cyclophosphamide, Vincristine, Prednisolone and Vinblastine for the Treatment of Large Cell Lymphoma in Cats.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.