MDose · Veterinary drug reference
TIER2 TOPIC: OPHTHALMIC GLAUCOMA DROPS (LATANOPROST / DORZOLAMIDE / TIMOLOL ± BRIMONIDINE)
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Primary glaucoma (latanoprost = biggest single-agent IOP reduction) + contralateral-eye prophylaxis (timolol/dorzolamide); secondary glaucomas (dorzolamide — no pupil effect)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Primary glaucoma (latanoprost = biggest single-agent IOP reduction) + contralateral-eye prophylaxis (timolol/dorzolamide); secondary glaucomas (dorzolamide — no pupil effect) — Extra-label (human ophthalmics)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Secondary glaucoma (dorzolamide); latanoprost ineffective/contraindicated (Studer)
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Secondary glaucoma (dorzolamide); latanoprost ineffective/contraindicated (Studer) — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens0
No dose regimens recorded for this species selection.
Adverse effects5
Latanoprost: profound miosis, conjunctival hyperemia, irritation, anterior uveitis risk — Expected/possible
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Latanoprost: iris darkening (irreversible melanocyte stimulation — human) — Cosmetic-permanent
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Dorzolamide stinging (low pH) — Application pain
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Timolol: systemic β-blockade (bradycardia/bronchospasm — feline asthma caution) — Drop-absorption systemic effect
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Brimonidine: local allergy, dry mouth (human) — Occasional
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Monitoring1
Tonometry (IOP trends) — the only truth; pupil size; conjunctival reaction; vision assessment
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions6
Latanoprost in cats (ineffective) and horses (painful, ineffective); timolol in asthmatic cats (relative)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Miotic agents (latanoprost) contraindicated-adjacent in anterior lens luxation/uveitis glaucoma variants — pupil constriction worsens pupillary-block scenarios per ophthalmology practice
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Power ranking in dogs: latanoprost > dorzolamide > timolol for IOP reduction — and combos beat singles (the Cosopt + latanoprost stacking pattern).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Timolol's honest job: contralateral-eye prophylaxis after one eye lost to primary glaucoma (3–10 mmHg isn't rescue therapy).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Latanoprost BID in dogs (not human QD) — the canine uveal tract burns through it in 12–15 h.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions2
Deliberate combos — Latanoprost + CAI (synergy); dorzolamide + timolol (Cosopt)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Systemic β-blockers + timolol drops — Addative β-blockade
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Topical drops; standard label cautions.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., ophthalmic appendix (latanoprost ~p.1196–1197; dorzolamide ~p.1191–1192; timolol ~p.1193–1194; brimonidine ~p.1189–1190) — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Sources: Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.