MDose · Veterinary drug reference
TILMICOSIN
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications3
BRD/pneumonic pasteurellosis (Mannheimia/Pasteurella)
CattleSheep / goatOn-label (ON_LABEL)2 source records · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: BRD/pneumonic pasteurellosis (Mannheimia/Pasteurella) — Authorized (label)
- Sheep / goat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: BRD/pneumonic pasteurellosis (Mannheimia/Pasteurella) — Authorized (label)
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Medicated FEED only (Pulmotil) — injection FATAL in swine
SwineOn-label (ON_LABEL)1 source record · View provenance
- Swine · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Medicated FEED only (Pulmotil) — injection FATAL in swine — Authorized (feed form)
- Swine · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects51
IM/SC tissue reactions, edema, necrosis (trim loss) — Route-related
CattleSheep / goatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Sheep / goat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Fatal cardiovascular toxicity (IV, overdose, wrong species) — The defining risk
CattleSwineNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Swine · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Death8 reports
- Accidental exposure2 reports
- Bradycardia2 reports
- Death by euthanasia2 reports
- Dyspnoea2 reports
- Polypnoea2 reports
- Tachycardia2 reports
- Vocalisation2 reports
- Apnoea1 reports
- Apprehension1 reports
- Bradypnoea1 reports
- Cardiac arrest1 reports
Cat
- Death3 reports
- Abnormal radiograph finding1 reports
- Anaemia NOS1 reports
- Blood dyscrasia NOS1 reports
- Convulsion1 reports
- Death by euthanasia1 reports
- Diarrhoea1 reports
- Dyspnoea1 reports
- Fever1 reports
- Hepatomegaly1 reports
- Icterus1 reports
- Mydriasis1 reports
Monitoring1
Clinical response; injection sites; any human accidental exposure = immediate medical care |
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
IV, powered syringes, swine injection, camelids (question-marked), horses (potentially fatal)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Human-exposure emergency protocol; avoid eyes
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The pharmacy-law star: Micotil's human-fatality profile (cardiovascular collapse from a needlestick-scale accident) drives the "no powered syringes + emergency number on the box" dispensing culture — Elanco's warning card exists because people died.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cattle q72h dosing = the long-tissue-persistence macrolide convenience, same logic as tulathromycin's single shot.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Epinephrine + tilmicosin increased mortality in swine — one more "not everything resuscitates" entry alongside α2-TMPS.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions2
Epinephrine — ↑ mortality (swine data) — the class surprise
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Erythromycin-class interactions — See erythromycin
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Macrolide (50S) with long tissue persistence; BRD breakpoint 32 µg/mL
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The toxicity identity — Cardiovascular-target lethality: humans injected accidentally can DIE; IV 5 mg/kg kills cattle; SC 150 mg/kg fatal
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Epinephrine + tilmicosin (swine) = increased mortality — Documented
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Label statements; not for dairy (class residue logic).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1121–1123 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references13
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Taste-masked tilmicosin-loaded nanostructured lipid carriers at pilot scale for improved bioavailability and enhanced efficacy against Salmonella infection in swine.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of Newer Veterinary Macrolide Antimicrobials on the CYP3A-Dependent Metabolism in Cattle Liver Microsomes: Potential Metabolic Drug-Drug Interaction with Monensin.
Study summary not available in the imported record. Open the original citation to review the study.
- Dose Optimization of Tilmicosin against Pasteurella multocida in Swine by Physiologically Based Pharmacokinetic-Pharmacodynamic Model.
Study summary not available in the imported record. Open the original citation to review the study.
- Novel Recombinase Polymerase Amplification Assay Is Sensitive for Detection of Macrolide Resistance Genes Relevant to Bovine Respiratory Disease Management in Feedlot Calves.
Study summary not available in the imported record. Open the original citation to review the study.
- Prevalence of the cfr gene and co-dissemination with the fosD gene in swine-derived Staphylococcus aureus.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.