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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Short-term adjunct anticonvulsant (epilepsy bridging); long-term adjunct if standard drugs fail — tolerance develops within weeks
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Short-term adjunct anticonvulsant (epilepsy bridging); long-term adjunct if standard drugs fail — tolerance develops within weeks — Extra-label (human drug; C-IV)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Longer-term adjunctive anticonvulsant; anxiolytic
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Longer-term adjunctive anticonvulsant; anxiolytic — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects48
Sedation, ataxia — Most prevalent
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Possible hepatic necrosis — Idiosyncratic; rarer than diazepam
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Tolerance to anticonvulsant effect — Weeks of therapy
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Withdrawal seizures on abrupt stop — Chronic use
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Lethargy (see also Central nervous system depression in 'Neurological')3 reports
- Abnormal urine odour2 reports
- Diarrhoea2 reports
- Elevated bile acids2 reports
- Falling2 reports
- Fever2 reports
- Hepatic encephalopathy2 reports
- Lethargy (see also Central nervous system depression in Neurological)2 reports
- Bacterial skin infection NOS1 reports
- Blindness1 reports
- Clumsy1 reports
- Decreased urine concentration1 reports
Cat
- Aggression1 reports
- Drooling1 reports
- Elevated creatine-kinase (CK)1 reports
- Growling1 reports
- Hyperglycaemia1 reports
- Hypokalaemia1 reports
- Lack of efficacy - NOS1 reports
- Lateral recumbency1 reports
- Tremor1 reports
- Unable to stand1 reports
Monitoring1
Seizure frequency, sedation/ataxia; liver values in cats on prolonged therapy; phenobarbital levels when co-used
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications3
Benzo hypersensitivity, narrow-angle glaucoma, significant liver disease; myasthenia gravis (exacerbation)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Reported safer than other benzodiazepines for liver dysfunction (per source table)
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Table 1 (p.630), row: Clonazepam, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
- Cat · Table 1 (p.630), row: Clonazepam, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
Precautions4
Taper to discontinue when used for seizures; monitor LFTs in cats
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The tolerance clock is the clinical limiter: brilliant for 2–4 week epilepsy bridging (e.g., while titrating a new maintenance drug), unreliable as chronic canine monotherapy.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
"Safer than diazepam for the feline liver" — relative, not absolute: still monitor LFTs.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Perrin cross-check: dog 0.1–1 mg/kg q8–12h and cat 0.05–0.2 mg/kg q12–24h behavioral windows match Plumb's ranges ✓.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Phenobarbital — Mutual metabolism effects — reduce PB dose 10–20% when adding
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Other CNS depressants — Additive
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
CYP inhibitors — ↑ levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — GABA-A potentiation (class)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hepatic risk — Idiosyncratic hepatic necrosis possible — considered LESS likely than diazepam
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Tolerance — Anticonvulsant efficacy fades over weeks (esp. dogs)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Avoid (class).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 298–299; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references20
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Animal behavior case of the month. Spinning.
Study summary not available in the imported record. Open the original citation to review the study.
- First report of malignant hyperthermia syndrome in an American Guinea hog.
Study summary not available in the imported record. Open the original citation to review the study.
- Pseudo-orthostatic tremor in a cat.
Study summary not available in the imported record. Open the original citation to review the study.
- Pharmacokinetics of oral clonazepam in growing commercial pigs (Sus scrofa domestica).
Study summary not available in the imported record. Open the original citation to review the study.
- The anthelmintic meclonazepam activates a schistosome transient receptor potential channel.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Perrin C, Seksel K, Landsberg GM. Appendix: Drug Dosage Chart. Vet Clin Small Anim 2014;44:629-632.; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.