MDose · Veterinary drug reference
SPECTINOMYCIN (SPECTINOMYCIN SULFATE)
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Source overview
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications1
INDICATIONS AND USAGE Mannheimia haemolytica, Pasteurella multocida, Histophilus somni. SpectoGard Sterile Solution is indicated for the treatment of bovine respiratory disease (pneumonia) associated withand
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens1
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
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Adverse effects19
ADVERSE REACTIONS The use of SpectoGard (spectinomycin sulfate) Sterile Solution may result in mild swelling at the injection site.Anaphylactic reactions may occur in animals previously sensitized.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Death2 reports
- Diarrhoea2 reports
- Emesis2 reports
- Lethargy (see also Central nervous system depression in 'Neurological')2 reports
- Anorexia1 reports
- Cough1 reports
- Dry eye1 reports
- Increased respiratory rate1 reports
- PR-INTEST, LESION(S)1 reports
- PR-LIVER, LESION(S)1 reports
- PR-LUNG(S), EDEMA1 reports
- PR-LUNG(S), LESION(S)1 reports
Contraindications1
CONTRAINDICATIONS AS with all drugs, the use of SpectoGard Sterile Solution is contraindicated in animals previously found to be hypersensitive to the drug.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Precautions2
Human Warnings NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN. As with other antibiotics, allergic reactions may occur in previously sensitized individuals. Repeated or prolonged exposure may lead to sensitization. Avoid direct contact with skin, eyes, mouth, and clothing. Persons with a known hypersensitivity to spectinomycin should avoid exposure to this product. In case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposure, wash with soap and water. Seek medical attention if allergic reactions occur. The safety data sheet (SDS) contains more detailed occupational safety information. To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet, contact Bimeda, Inc. at 1-888-524-6332. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
PRECAUTIONS The safety of SpectoGard Sterile Solution has not been determined for cattle intended for breeding. Discoloration at the injection site may persist beyond 11 days after injection. This may necessitate trimming of the injection site and surrounding tissues at slaughter.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 42232-9 (PRECAUTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics1
CLINICAL PHARMACOLOGY Microbiology Spectinomycin is bacteriostatic and exerts its antibacterial effect by binding to the 30S ribosome and inhibiting bacterial protein synthesis. Spectinomycin has activity against a variety of gram-negative bacteria, some mycoplasma, and a limited number of gram-positive bacteria. Generally, it is not active against anaerobic bacteria. in vitro in vivo Mannheimia haemolytica, Pasteurella multocida, Histophilus somni Spectinomycin has demonstratedandactivity against the three major pathogenic bacteria (and) associated with bovine respiratory disease (pneumonia). in vitro Actinomyces pyogenes, Mycoplasma bovis, Mycoplasma dispar in vitro Spectinomycin has also demonstratedactivity againstand. The clinical significance of thisactivity in cattle has not been demonstrated.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34090-1 (CLINICAL PHARMACOLOGY SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Literature references12
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Evolutionary dynamics of the multidrug-resistant Salmonella Infantis harbouring the pESI megaplasmid across Europe.
Study summary not available in the imported record. Open the original citation to review the study.
- Disposition kinetics and tissue residues of Lincomycin following intravenous, intramuscular and single and multiple oral dosing in domestic geese (Anser anser domesticus).
Study summary not available in the imported record. Open the original citation to review the study.
- A systematic review and meta-analysis on the efficacy of antibiotic treatment in controlling colibacillosis in broiler production.
Study summary not available in the imported record. Open the original citation to review the study.
- Antimicrobial Susceptibility Profiles of Staphylococcus aureus and Streptococcus spp. Isolates from Clinical Cases of Waterfowl in Hungary Between 2022 and 2023.
Study summary not available in the imported record. Open the original citation to review the study.
- Antimicrobial Susceptibility Profiles of Escherichia coli Isolates from Clinical Cases of Ducks in Hungary Between 2022 and 2023.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: DailyMed, U.S. National Library of Medicine; PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.