MDose · Veterinary drug reference
ROMIFIDINE
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications3
Sedation/analgesia for handling, exams, minor procedures; preanesthetic
HorseOn-label (ON_LABEL)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Sedation/analgesia for handling, exams, minor procedures; preanesthetic — Authorized (US label)
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Sedation (EU label)
CatOn-label (ON_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Sedation (EU label) — Authorized (EU)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Epidural analgesia protocols (extra-label — FARAD for withdrawals)
CattleExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Epidural analgesia protocols (extra-label — FARAD for withdrawals) — Extra-label
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects3
Bradycardia, AV block (class) — Expected physiology
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Mild ataxia — Less than xylazine (reputation)
HorseNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Diarrhoea1 reports
Monitoring1
HR/rhythm, sedation depth, RR; the α2-class monitoring set
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Class: severe cardiac disease/heart block (see xylazine.md)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Cattle epidural romifidine+morphine (12 h analgesia) = the large-animal neuroaxial gem from this file.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cattle = unapproved (FARAD); combine-with-anticholinergic only in exercise-tolerant, cardiac-normal patients
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The α2 trio card: xylazine (workhorse), detomidine (deep+long, µg-discipline, TMPS warning), romifidine (smoother, horse-label, intermediate) — same receptor, three clinical personalities.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The cat 400-µg/kg + atipamezole 400-µg/kg pairing is the cleanest 1:1 reversal arithmetic in the α2 family.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
IV TMPS — The α2-class fatal-dysrhythmia warning (see detomidine.md — same class rule)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Atipamezole — Reversal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Other depressants — Additive
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics2
Mechanism — α2-agonist — relative to xylazine: less ataxia/less colic-effect profile; "smoother" reputation; to detomidine: intermediate duration/potency
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Reversal — Atipamezole (1:1 µg-basis per the cat label example)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Class: late pregnancy + food-animal cautions (label).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1047–1049 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references19
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- The effect of romifidine on endoscopic grading of laryngeal function in horses.
Study summary not available in the imported record. Open the original citation to review the study.
- Comparing isoflurane and desflurane: A prospective randomised blinded clinical trial in horses undergoing elective surgery.
Study summary not available in the imported record. Open the original citation to review the study.
- Comparative antinociceptive and sedative effects of epidural romifidine and xylazine in dromedary Camels (Camelus dromedarius).
Study summary not available in the imported record. Open the original citation to review the study.
- Comparison of Ketamine/Diazepam and Tiletamine/Zolazepam Combinations for Anaesthesia Induction in Horses Undergoing Partial Intravenous Anaesthesia (PIVA): A Retrospective Clinical Study.
Study summary not available in the imported record. Open the original citation to review the study.
- Influence of acepromazine on the cardiovascular effects of dobutamine in isoflurane-anaesthetised horses premedicated with romifidine.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.