MDose · Veterinary drug reference
PROSTAGLANDINS LUTEOLYTIC
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications4
Luteolysis: estrus synchronization, pyometra, endometritis, mummified fetus/fetal maceration; silent-estrus resolution
CattleOn-label (ON_LABEL)1 source record · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Luteolysis: estrus synchronization, pyometra, endometritis, mummified fetus/fetal maceration; silent-estrus resolution — Authorized (label)
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Estrus manipulation (short-cycle/breeding scheduling); induction of luteolysis — NOT for pregnant mares unless abortion intended
HorseExtra-label (EXTRA_LABEL)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Estrus manipulation (short-cycle/breeding scheduling); induction of luteolysis — NOT for pregnant mares unless abortion intended — Authorized/extra-label contexts
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Estrus synchronization, abortion induction (per label)
SwineOn-label (ON_LABEL)1 source record · View provenance
- Swine · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Estrus synchronization, abortion induction (per label) — Authorized
- Swine · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Pyometra (medical management — largely displaced by aglepristone/surgery)
Other speciesExtra-label (EXTRA_LABEL)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Pyometra (medical management — largely displaced by aglepristone/surgery) — Extra-label
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
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Adverse effects4
Uterine contractions/straining, discomfort — Expected pharmacology
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Bronchospasm (human exposure) — Class effect
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hypersalivation/restlessness (dinoprost esp.) — Transient
CattleNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hypotension/colic-signs transient — Possible
HorseNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Monitoring1
Estrus response post-treatment (24–96 h windows), CL status, pregnancy-status confirmation BEFORE dosing (the #1 error class)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Pregnant animals (unless termination intended); handlers pregnant/asthmatic
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Closed-cervix pyometra (bitch — uterine rupture theoretical); stress-compromised animals
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The double-commandment: confirm NOT pregnant before dosing (unless terminating), and pregnant/asthmatic handlers don't touch the bottle — both are label-level rules.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Synchronization arithmetic (2 shots × 11 days) exists because of CL-age sensitivity — days 5–17 responsive, otherwise you paid for a placebo.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cloprostenol-vs-dinoprost: same destination (luteolysis), different potency/units — µg vs mg discipline like the α2 family.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Progestins (altrenogest) — Opposing actions
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Oxytocin — Synergistic uterotonia — sequencing in protocols
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
NSAIDs (PG-synthesis inhibitors) — Theoretical blunting
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Exogenous PGF2α: luteal regression (corpus luteum death → progesterone fall → estrus/termination); also uterotonic/smooth-muscle effects; cloprostenol = synthetic analog (more potent, longer)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Functional CL required — Works ONLY on a responsive corpus luteum (days 5–17 cattle cycle) — day-1–4 CLs resist (the timing science of synchronization)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Bronchoconstrictor class effect — Asthmatic-human handlers + bronchospastic patients caution (PGF class)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Terminates pregnancy (that's the mechanism) — never in intended pregnancies; label warnings explicit.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 304–306 (cloprostenol), p. 416–418 (dinoprost) — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references20
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Evaluation of luteolytic activity and reproductive outcomes in ewes following single and split dose cloprostenol during the breeding season.
Study summary not available in the imported record. Open the original citation to review the study.
- Prostaglandin-induced luteolysis and estrous expression in dairy heifers: applications of ovulation prediction based on automated activity monitoring system.
Study summary not available in the imported record. Open the original citation to review the study.
- Early Embryonic Development in Agriculturally Important Species.
Study summary not available in the imported record. Open the original citation to review the study.
- Luteal tissue blood flow and side effects of horse-recommended luteolytic doses of dinoprost and cloprostenol in donkeys.
Study summary not available in the imported record. Open the original citation to review the study.
- History, insights, and future perspectives on studies into luteal function in cattle.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
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