MDose · Veterinary drug reference
DEXTROAMPHETAMINE METHYLPHENIDATE
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications1
Narcolepsy/cataplexy (diagnostic trial + treatment, usually supplementing imipramine); hyperkinesis/hyperactivity syndrome
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Narcolepsy/cataplexy (diagnostic trial + treatment, usually supplementing imipramine); hyperkinesis/hyperactivity syndrome — Extra-label (human drugs; C-II controlled)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens3
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects3
CNS stimulation signs: restlessness, tremors, anorexia, insomnia — Primary
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Tachycardia, hypertension, mydriasis — Sympathomimetic
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Monitoring1
Clinical: Narcoleptic episode frequency, behavioral response; HR; appetite
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Seizures, cardiac disease, hypertension, aggression
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Narrow safety margin in dogs; absolutely lethal-adjacent in cats
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The narcolepsy toolbox: imipramine (base) + methylphenidate (layer) — and the diagnosis itself is response-to-stimulant (what makes a dog sleepless, wakes a narcoleptic).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
C-II dispensing is the pharmacy headline: locked storage, no refills theater, precise records — the tightest control class in the library.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The irony file: a drug that calms hyperkinetic dogs by stimulating — the "paradoxical response" that defined canine hyperkinesis syndrome diagnostically.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cat exposure = emergency (5 mg tablet → severe tox signs) — owner-counseling point.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
MAOIs — Hypertensive crisis risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Other sympathomimetics — Additive
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Anesthetics (halogenated) — Arrhythmia risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Amphetamine-like CNS stimulation (catecholamine release/reuptake blockade); weak sympathomimetic periphery
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Dog PK (methylphenidate IR) — Peak ~15 min; t½ ~1 h — short-acting
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Safety margin — Toxicity from ≥1 mg/kg; fatality reported at 3.1 mg/kg; lab dogs survived 20 mg/kg/day × 90 d
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Teratogenic only at massive doses (200 mg/kg/day rabbits); avoid regardless (C-II).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 813–814 (methylphenidate); Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 (both agents) — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references3
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Blockade by reserpine of methylphenidate-induced release of brain dopamine.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of psychostimulants on aggression.
Study summary not available in the imported record. Open the original citation to review the study.
- The efficacy of managing postanaesthetic respiratory depression with analeptics.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.