MDose · Veterinary drug reference
AMIKACIN
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Severe gram-negative infections (Klebsiella, Proteus, Pseudomonas, Salmonella, Enterobacter, Serratia, Staph) — including gentamicin-resistant Pseudomonas/Proteus/Serratia; sepsis
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Severe gram-negative infections (Klebsiella, Proteus, Pseudomonas, Salmonella, Enterobacter, Serratia, Staph) — including gentamicin-resistant Pseudomonas/Proteus/Serratia; sepsis — Amiglyde-V FDA-approved (dogs); much use extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Severe gram-negative infections (Klebsiella, Proteus, Pseudomonas, Salmonella, Enterobacter, Serratia, Staph) — including gentamicin-resistant Pseudomonas/Proteus/Serratia; sepsis — Amiglyde-V FDA-approved (dogs); much use extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens7
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects137
Nephrotoxicity (proximal tubular necrosis) — The class risk; usually reversible if caught (↑BUN/Cr, ↓USG, proteinuria, casts)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Ototoxicity (8th CN, may be irreversible) — Amikacin leans AUDITORY (vs gentamicin's vestibular)
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Neuromuscular blockade — Myasthenia gravis exacerbation
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Injection-site pain, hypersensitivity — Occasional
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Death by euthanasia7 reports
- Lack of efficacy - NOS7 reports
- Death6 reports
- Decreased appetite6 reports
- Pain NOS6 reports
- Unable to stand6 reports
- Vomiting6 reports
- Elevated serum alkaline phosphatase (ALP)5 reports
- Lethargy (see also Central nervous system depression in Neurological)5 reports
- Leucocytosis NOS5 reports
- Elevated alanine aminotransferase (ALT)4 reports
- Limb weakness4 reports
Cat
- Head bobbing3 reports
- Blindness2 reports
- Elevated alanine aminotransferase (ALT)2 reports
- Elevated aspartate aminotransferase (AST)2 reports
- Elevated blood urea nitrogen (BUN)2 reports
- Neurological signs NOS2 reports
- Vocalisation2 reports
- Alopecia1 reports
- Anorexia1 reports
- Ataxia1 reports
- CULTURE/TITER DATA ABNORMAL1 reports
- Death1 reports
Monitoring1
Urinalysis (USG, protein, casts) + BUN/creatinine at baseline then q2–3 days; serum peaks/troughs when possible; hydration
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions6
Preexisting renal disease (extreme caution + monitoring + interval extension); neonatal/geriatric; dehydration, fever, sepsis; "working" dogs (hearing/service); sighthounds (reduce dose); myasthenia gravis
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindicated in rabbits (GI flora catastrophe)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Once-daily dosing is the standard: higher peaks → concentration-dependent kill + post-antibiotic effect, and low troughs REDUCE nephrotoxicity (less tubular uptake) — the one exception is the neutropenic patient (q8h divided).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Amikacin retains activity against many gentamicin-resistant gram-negatives — the go-to when susceptibility data point that way.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Overdose rescue: hemodialysis (rarely available), peritoneal dialysis, or beta-lactam complexation (less effective for amikacin than gentamicin/tobramycin).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions5
Loop diuretics (furosemide) — ↑ ototoxicity/nephrotoxicity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Other nephrotoxins (amphotericin B, NSAIDs, cisplatin) — Additive renal injury
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Beta-lactams — Synergy vs Pseudomonas (deliberate combo) — but chemical inactivation if mixed in vitro
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Neuromuscular blockers, anesthetics — Enhanced neuromuscular blockade
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Acepromazine/vasodilators — Reduced renal clearance → accumulation
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics4
Absorption — None orally (gut sterilization only); >90% from IM/SC
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Distribution — Extracellular fluid; Vd 0.15–0.3 L/kg (dog/cat)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — 0.5–2 h (dog/cat)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Glomerular filtration (unchanged)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Human FDA category C; canine/feline class C (last resort). Crosses placenta — fetal ototoxicity/nephrotoxicity possible. Excreted in milk (mainly colostrum-period concern).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 63–65; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 25–26 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references20
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Successful treatment of Mycobacterium abscessus infection with surgical excision and systemic antibiotics in 2 dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Lactic acid bacterial strains isolated from Attiéké (semolina cassava): bio-tools for combating emergent pathogens in the context of climate change.
Study summary not available in the imported record. Open the original citation to review the study.
- Fluorometholone-antibiotic interactions in canine ocular bacteria: in vitro susceptibility changes in common corneal infection pathogens.
Study summary not available in the imported record. Open the original citation to review the study.
- Comparative Phenotypic and PCR-Based Methicillin Resistance Characterization of Clinical Canine Staphylococcus pseudintermedius.
Study summary not available in the imported record. Open the original citation to review the study.
- Dual-action antimicrobial peptide therapy: disrupting biofilm formation and targeting bacterial DNA for enhanced treatment of Pseudomonas aeruginosa endophthalmitis.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.