Favorites and recent references stay on this device. No patient data is stored.
Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
No clinical assertions recorded for an overview.
View full clinical evidence and sources ↓Clinical evidence
Dose regimens0
No dose regimens recorded for this species selection.
Adverse effects114
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- INEFFECTIVE, HEARTWORM ADULTS3,883 reports
- Vomiting2,596 reports
- Lack of efficacy (endoparasite) - heartworm2,382 reports
- Injection site swelling2,216 reports
- Injection site pain1,378 reports
- Pain NOS1,236 reports
- Anorexia1,185 reports
- Diarrhoea1,133 reports
- Depression1,082 reports
- Lethargy (see also Central nervous system depression in 'Neurological')1,015 reports
- Fever964 reports
- Death922 reports
Cat
- Death5 reports
- Accidental exposure3 reports
- Depression2 reports
- Respiratory distress2 reports
- Vocalisation2 reports
- Cardiorespiratory arrest1 reports
- Diarrhoea1 reports
- Drug administration error1 reports
- Dyspnoea1 reports
- Heavy breathing1 reports
- Lung oedema1 reports
- Polypnoea1 reports
Literature references14
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Non-Arsenical heartworm adulticidal therapy using topical moxidectin-imidacloprid and doxycycline: A prospective case series.
Study summary not available in the imported record. Open the original citation to review the study.
- Use of Slow-Release Injectable Moxidectin for Treatment of Dirofilaria immitis Infection During Pregnancy.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy of imidacloprid 10%/moxidectin 2.5% spot on (Advocate®, Advantage Multi®) and doxycycline for the treatment of natural Dirofilaria immitis infections in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Variation of the adulticide protocol for the treatment of canine heartworm infection: Can it be shorter?
Study summary not available in the imported record. Open the original citation to review the study.
- Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.