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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Chronic constipation / megacolon (first-line prokinetic for feline constipation)
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Chronic constipation / megacolon (first-line prokinetic for feline constipation) — Extra-label (compounded)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
GI stasis/reflux esophagitis, megaesophagus regurgitation, esophagitis stricture prevention, detrusor atony
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: GI stasis/reflux esophagitis, megaesophagus regurgitation, esophagitis stricture prevention, detrusor atony — Extra-label (compounded)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects203
Cardiac arrhythmias (QT prolongation) — The reason for human withdrawal — ECG monitor susceptible patients
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Diarrhea, cramping — Possible
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Overdose: ataxia, hypersalivation, muscle fasciculations, hyperthermia, seizures — APCC reports
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting13 reports
- Death by euthanasia9 reports
- Diarrhoea9 reports
- Abnormal ultrasound finding8 reports
- Anorexia7 reports
- Decreased appetite7 reports
- Lack of efficacy - NOS7 reports
- Lethargy (see also Central nervous system depression in Neurological)7 reports
- Other abnormal test result NOS7 reports
- Regurgitation7 reports
- Weight loss7 reports
- Abdominal discomfort6 reports
Cat
- Constipation13 reports
- Decreased appetite13 reports
- Vomiting12 reports
- Weight loss12 reports
- Death by euthanasia10 reports
- Lack of efficacy - NOS9 reports
- Ketosis8 reports
- Anorexia7 reports
- Ataxia7 reports
- Elevated blood urea nitrogen (BUN)7 reports
- Other abnormal test result NOS7 reports
- Elevated creatinine6 reports
Monitoring1
Fecal consistency/output; ECG in cardiac patients; electrolytes with concurrent diuretics
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
GI perforation/obstruction, hemorrhage; hypersensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Hepatic insufficiency — halve the dose; cardiac disease / arrhythmia history
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Timing is the prescription: 15–30 minutes BEFORE meals — giving it with food wastes the prokinetic window.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Withdrawn from the human market for fatal arrhythmias (QT) — the compounding-only status makes interaction screening (azole antifungals, macrolides) mandatory before dispensing.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
For feline megacolon, cisapride + lactulose + dietary fiber is the classic medical triad before subtotal colectomy is considered.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Activated charcoal binds unabsorbed cisapride in overdose.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions6
CYP3A4 inhibitors: ketoconazole/itraconazole/fluconazole, chloramphenicol, cimetidine, erythromycin-class macrolides, grapefruit — ↑ cisapride levels → cardiotoxicity risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
QT-prolonging drugs: amiodarone, clarithromycin, moxifloxacin, procainamide, quinidine, sotalol, TCAs — Additive QT risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Anticholinergics — Block prokinetic effect
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Benzodiazepines — Enhanced sedation
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Warfarin — Enhanced anticoagulation
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics2
Metabolism — Hepatic CYP3A4 (human)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Onset — Prokinetic effect on feeding-related timing — give pre-meals
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Excreted in milk in low levels — caution in nursing mothers.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 277–278; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 161–162 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references18
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- The 4 prokinetic drugs metoclopramide, cisapride, pyridostigmine, and capromorelin do not increase fecal output or food intake in healthy New Zealand rabbits (Oryctolagus cuniculus).
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of Cisapride, Buprenorphine, and Their Combination on Gastrointestinal Transit in New Zealand White Rabbits.
Study summary not available in the imported record. Open the original citation to review the study.
- Comparative Efficacy of the Prokinetic Effects of Cisapride and Tegaserod in Equines.
Study summary not available in the imported record. Open the original citation to review the study.
- A human population-based organotypic in vitro model for cardiotoxicity screening.
Study summary not available in the imported record. Open the original citation to review the study.
- The in vitro pharmacology and non-clinical cardiovascular safety studies of a novel 5-HT(4) receptor agonist, DSP-6952.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.