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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Aggression, stereotypic/compulsive behaviors; generalized anxiety; phobias/fears (adjunct)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Aggression, stereotypic/compulsive behaviors; generalized anxiety; phobias/fears (adjunct) — Extra-label (human drug)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Occasional use for anxiety/behavioral disorders
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Occasional use for anxiety/behavioral disorders — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens6
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects111
Anorexia, lethargy, GI effects, anxiety, irritability, insomnia/hyperactivity, panting — Profile not fully established
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Aggression in previously unaggressive dogs — Possible
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Behavior changes, anorexia, constipation, elimination-pattern changes — Feline profile
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Constipation (reported in cats)
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Table 1 (p.630), row: Paroxetine, Adverse Effects column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
- Cat · Table 1 (p.630), row: Paroxetine, Adverse Effects column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Lethargy (see also Central nervous system depression in 'Neurological')7 reports
- Vomiting6 reports
- Decreased appetite3 reports
- Lack of efficacy - NOS3 reports
- Anaemia NOS2 reports
- Anxiety2 reports
- Death by euthanasia2 reports
- Dermal thickening2 reports
- Ecchymosis2 reports
- Elevated blood urea nitrogen (BUN)2 reports
- Hypoproteinaemia2 reports
- Immune mediated haemolytic anaemia2 reports
Cat
- Behavioural disorder NOS3 reports
- Accidental exposure2 reports
- Ataxia2 reports
- Vomiting2 reports
- Abnormal Schirmer tear test1 reports
- Aggression1 reports
- Cataract1 reports
- Decreased activity1 reports
- Dilated pupils1 reports
- Elevated blood urea nitrogen (BUN)1 reports
- Eye disorder NOS (for photophobia see 'neurological')1 reports
- Faecal incontinence1 reports
Monitoring1
Behavioral response (6–8 week trials); appetite/weight; anxiety/aggression shifts; sedation
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications3
Hypersensitivity; MAO inhibitor co-therapy (selegiline, amitraz)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
MAOIs
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Table 1 (p.630), row: Paroxetine, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
- Cat · Table 1 (p.630), row: Paroxetine, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
Precautions4
Severe cardiac/renal/hepatic disease (reduce dose); seizure history (class); bleeding risk (platelet serotonin effect)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Paxil's personality: the most potent, most anticholinergic, most interaction-prone SSRI — and the one with the worst human discontinuation syndrome → always taper.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The "aggressive behavior in previously unaggressive dogs" line appears across the SSRI files — owner-warned monitoring matters in aggression cases specifically.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Perrin: constipation in cats is the paroxetine-specific feline note (vs fluoxetine's appetite suppression).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions4
MAOIs (selegiline, amitraz) — Serotonin syndrome — contraindicated
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Tramadol, trazodone, other serotonergics — Serotonin syndrome risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
CYP2D6 substrates — Paroxetine inhibits — levels rise
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
NSAIDs/anticoagulants — ↑ bleeding risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Potent SSRI (most serotonergic of the class)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Hepatic; potent CYP2D6 inhibitor — the interaction-heavy SSRI
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Withdrawal — Gradual taper after extended use — discontinuation syndrome notable
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Avoid (class caution).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 939–941; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references14
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats.
Study summary not available in the imported record. Open the original citation to review the study.
- Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM-I against influenza A Virus Infection.
Study summary not available in the imported record. Open the original citation to review the study.
- Real-World Data Insights into Antidepressant Prescription and Adherence During Pregnancy in Catalonia (Spain).
Study summary not available in the imported record. Open the original citation to review the study.
- Multifaceted analysis of equine cystic echinococcosis: genotyping, immunopathology, and screening of repurposed drugs against E. equinus protoscolices.
Study summary not available in the imported record. Open the original citation to review the study.
- Preparation of oyster peptide and Pfaffia glomerata pressed candy and its ameliorative effect on sexual dysfunction in male mice.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Perrin C, Seksel K, Landsberg GM. Appendix: Drug Dosage Chart. Vet Clin Small Anim 2014;44:629-632.; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.