MDose · Veterinary drug reference
TRIMETHOPRIM SULFADIAZINE
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
UTI, pyoderma, soft tissue infection, systemic infection, protozoal disease (toxoplasmosis, coccidiosis, Neospora, Hepatozoon — combined with other agents)
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: UTI, pyoderma, soft tissue infection, systemic infection, protozoal disease (toxoplasmosis, coccidiosis, Neospora, Hepatozoon — combined with other agents) — Authorized (TMP-sulfadiazine, some products); TMP-sulfamethoxazole extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: UTI, pyoderma, soft tissue infection, systemic infection, protozoal disease (toxoplasmosis, coccidiosis, Neospora, Hepatozoon — combined with other agents) — Authorized (TMP-sulfadiazine, some products); TMP-sulfamethoxazole extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects84
Keratoconjunctivitis sicca (may be irreversible) — Documented, can be permanent
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Acute hepatitis/icterus, hemolytic anemia, polyarthritis, facial swelling — Type I/III hypersensitivity
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hypothyroidism — With extended therapy, reversible
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Anorexia, crystalluria, hematuria, leukopenia/anemia — Reported
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Transient pruritus (post-IV) — Reported
HorseNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Other abnormal test result NOS3 reports
- Decreased red blood cell count2 reports
- Elevated total bilirubin2 reports
- Vomiting2 reports
- Appetite loss1 reports
- Blood in urine1 reports
- Decreased bowel movements1 reports
- Distension of abdomen1 reports
- Ear infection NOS1 reports
- Elevated alanine aminotransferase (ALT)1 reports
- Elevated blood urea nitrogen (BUN)1 reports
- Elevated serum alkaline phosphatase (SAP)1 reports
Cat
- Anorexia2 reports
- Elevated alanine aminotransferase (ALT)2 reports
- Elevated aspartate aminotransferase (AST)2 reports
- Lethargy (see also Central nervous system depression in 'Neurological')2 reports
- Neutropenia2 reports
- Non-regenerative anaemia2 reports
- Pain NOS2 reports
- Paresis2 reports
- Unable to stand2 reports
- Abnormal pupil light reflex1 reports
- Agitation1 reports
- Ataxia1 reports
Monitoring1
Tear production (Schirmer test) with prolonged use; CBC with long-term therapy; thyroid function if on extended treatment (effect is reversible)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Sulfonamide/thiazide/sulfonylurea hypersensitivity; severe renal/hepatic impairment; Doberman Pinschers — increased susceptibility to sulfonamide hypersensitivity, use with caution
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Urolithiasis risk (avoid in dogs prone to/with uroliths, dehydration, acidic urine)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Watch for KCS with prolonged use — this can become permanent if not caught early; consider baseline and periodic Schirmer tear tests on long courses.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Can cause a reversible functional hypothyroidism in dogs after ~2 weeks of treatment — don't misinterpret thyroid panels drawn during therapy.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Ineffective for abscesses/anaerobic infections — necrotic tissue material antagonizes the drug's mechanism.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions6
Cyclosporine — ↑ nephrotoxicity risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Digoxin — ↑ digoxin levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Methotrexate — ↑ toxicity risk (protein-binding displacement)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Phenytoin — ↑ half-life
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Warfarin — ↑ INR/PT
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Bioavailability — Well absorbed PO
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — Not detailed
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life (trimethoprim) — ~2.5h (dog)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Sulfa: acetylation/glucuronidation; TMP: oxide/hydroxyl metabolites
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Renal (glomerular filtration + tubular secretion) + hepatic
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Teratogenicity (cleft palate) reported. Papich canine/feline class B. Human newborns: kernicterus risk via milk/placenta (not described in animals but caution warranted).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1088–1090; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 818–820 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references16
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Comparative pharmacokinetics of trimethoprim-sulfadiazine and trimethoprim-sulfamethoxazole in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Newly isolated bacteriophages show efficacy and phage-antibiotic synergy in vitro against the equine genital pathogens Klebsiella pneumoniae and Pseudomonas aeruginosa.
Study summary not available in the imported record. Open the original citation to review the study.
- Red osier dogwood extract versus Trimethoprim-sulfadiazine (Part 1). Effects on the growth performance, blood parameters, gut histomorphometry, and Salmonella excretion of broiler chickens orally challenged with Salmonella Enteritidis.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of concentrated fecal microbiota transplant on the equine fecal microbiota after antibiotic-induced dysbiosis.
Study summary not available in the imported record. Open the original citation to review the study.
- 4-Arylthiosemicarbazide derivatives - Pharmacokinetics, toxicity and anti-Toxoplasma gondii activity in vivo.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.