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Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Babesia canis (FDA label); other Babesia species extra-label (B. gibsoni — reduces but may not eliminate carriage)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Babesia canis (FDA label); other Babesia species extra-label (B. gibsoni — reduces but may not eliminate carriage) — Authorized (label) / extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Cytauxzoon felis combination protocols (extra-label, referral-level)
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Cytauxzoon felis combination protocols (extra-label, referral-level) — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens2
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects129
Pain at injection — Most common
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cholinergic signs: salivation, nasal drip, brief vomiting, (horses: lacrimation/sweating 30 min) — Mild, transient
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Panting, diarrhea, restlessness, injection-site inflammation (rarely ulceration) — Less common
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Liver enzyme elevations at 1.5× dose — Overdose-context
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting28 reports
- Death25 reports
- Hypersalivation24 reports
- Diarrhoea21 reports
- Injection site swelling19 reports
- Depression15 reports
- Fever14 reports
- Injection site pain9 reports
- Weakness9 reports
- Injection site ulcer8 reports
- Elevated alanine aminotransferase (ALT)7 reports
- Trembling7 reports
Cat
- Gait abnormality6 reports
- Neuropathy NOS6 reports
- Death5 reports
- Hypersalivation4 reports
- Limping4 reports
- Accidental exposure2 reports
- Lameness2 reports
- Neurological signs NOS2 reports
- Prolapse of the nictitating membrane2 reports
- Acute renal failure1 reports
- Administration error NOS1 reports
- Anaemia NOS1 reports
Monitoring1
PCV/parasitemia (blood smear/PCR), cholinergic signs post-injection, injection sites, liver values if higher doses
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Patients exposed to cholinesterase inhibitors (pyridostigmine etc.) or organophosphate pesticides — additive cholinergic load
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Impaired pulmonary/hepatic/renal function; puppies/breeding animals
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The injection-day cholinergic show: drooling + runny nose for 30 minutes after the shot — warn the owner, it's expected, not an allergic reaction.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
IV = never (label prohibition); IM/SC only.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Babesia species split matters: B. canis responds to imidocarb; B. gibsoni needs combination therapy — PCR speciation guides expectations.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Tick control completes the program (Rhipicephalus/vector transmission).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions2
Cholinesterase inhibitors, organophosphates/carbamate pesticides — Contraindicated combos
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Atropine — Pre-treatment blunts cholinergic signs (used by some clinicians)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Carbanilide — disrupts protozoal metabolism/replication in RBCs
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cholinergic effects — Anticholinesterase-like activity → the salivation/nasal-drip reactions
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Margins — 9.9 mg/kg (1.5×) = liver enzyme bumps + injection reactions; horse LD50 16 mg/kg
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Safety not established in puppies/pregnant/lactating/breeding — caution.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 636–637 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references19
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Clinicopathological abnormalities, treatment, and outcome in in a 45-day-old puppy with acute Babesia canis infection.
Study summary not available in the imported record. Open the original citation to review the study.
- Drug resistance in protozoan blood parasites of livestock across the Middle East and North Africa.
Study summary not available in the imported record. Open the original citation to review the study.
- Retrospective analysis of anamnesis, clinical signs, therapy, and outcome in 342 dogs with acute Babesia canis infections.
Study summary not available in the imported record. Open the original citation to review the study.
- Clinicopathological abnormalities and outcome of acute Babesia canis infections in 23 dogs treated with imidocarb dipropionate.
Study summary not available in the imported record. Open the original citation to review the study.
- Treatment failure in a dog with acute Babesia canis infection using lower-range therapeutic doses of imidocarb dipropionate.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.