Favorites and recent references stay on this device. No patient data is stored.
Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
No clinical assertions recorded for an overview.
View full clinical evidence and sources ↓Clinical evidence
Dose regimens0
No dose regimens recorded for this species selection.
Adverse effects200
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting15,966 reports
- Diarrhoea6,119 reports
- Lethargy (see also Central nervous system depression in 'Neurological')5,703 reports
- Lack of efficacy (ectoparasite) - tick NOS4,987 reports
- Lack of efficacy (ectoparasite) - flea4,527 reports
- Seizure NOS4,402 reports
- Lack of efficacy (bacteria) - Borrelia3,553 reports
- Lack of efficacy (tick)3,389 reports
- Skin disorders NOS2,625 reports
- Lack of efficacy (bacteria) - NOS2,606 reports
- Pruritus2,443 reports
- Itching2,148 reports
Cat
- Vomiting14 reports
- Administration error NOS8 reports
- Lethargy (see also Central nervous system depression in Neurological)7 reports
- Hyperactivity6 reports
- Not eating6 reports
- Inappetence5 reports
- Itching5 reports
- Lack of efficacy (ectoparasite) - flea5 reports
- Lethargy (see also Central nervous system depression in 'Neurological')5 reports
- Panting5 reports
- Accidental exposure4 reports
- Ataxia4 reports
Literature references20
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Efficacy of afoxolaner (NexGard®) for the treatment of myiasis caused by the zoonotic tumbu fly, Cordylobia anthropophaga, in domestic dogs under field conditions.
Study summary not available in the imported record. Open the original citation to review the study.
- Comparative speed of kill of induced Ixodes scapularis infestations following treatment of dogs with endectocides containing either sarolaner (Simparica Trio™), afoxolaner (NexGard(®) PLUS), or lotilaner (Credelio Quattro™).
Study summary not available in the imported record. Open the original citation to review the study.
- Patterns of antiparasitic usage in Golden Retriever breed of dogs: A 9-year cohort study.
Study summary not available in the imported record. Open the original citation to review the study.
- Saving a species, one mite at a time: efficacy of afoxolaner (NexGard®) against Macronyssidae mites in the critically endangered Aeolian wall lizard (Podarcis raffonei).
Study summary not available in the imported record. Open the original citation to review the study.
- Comparative efficacy of six monthly doses of Simparica Trio(®) (sarolaner, moxidectin, and pyrantel chewable tablets) versus NexGard(®) Plus (afoxolaner, moxidectin, and pyrantel chewable tablets) against a macrocyclic lactone-resistant Dirofilaria immitis isolate in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.